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題 名 | Absence of Interleukin 2 and Tumor Necrosis Factor Changes in Cats Infected with Feline Immunodeficiency Virus and Toxoplasma gondii=感染有貓免疫缺陷病毒及弓蟲之貓隻其Interleukin 2 及 Tumor Necrosis Factor 分泌量並無變化 |
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作 者 | 林大盛; | 書刊名 | 國立臺灣大學農學院研究報告 |
卷 期 | 34:3 1994.09[民83.09] |
頁 次 | 頁218-226 |
分類號 | 437.246 |
關鍵詞 | 貓; 淋巴球; 巨噬細胞; 貓免疫缺陷病毒; 弓蟲; Cat; Interlukin 2; Tumor necrosis factor; Lymphocyte; Macrophage; FIV; Toxoplasma gondii; |
語 文 | 英文(English) |
中文摘要 | 一些研究指出當人感染有人免疫缺陷病毒第一型 (human immuno-deficiency virus type 1, HIV-1)或貓感染有貓免疫缺陷病毒 (felineimmunodeficiency virus,FIV)時,若同時也感染有其他病原,例如弓蟲,則更 能促進疾病進入AIDS(acquired immune deficiency syndrome)期。一般認為此乃因T 細胞被同時感染之病原激活所致。活化之T細胞可釋放出一些細胞因子,此等因 子不但可和interleukin 2(IL-2)之enhancer element(稱kB)結合,同時也可和HIV-1之 long terminal repeat結合,致使病毒大量繁殖。由於與kB結合之因子主要由tumor necrosis factor(TNF)所激發,同時T細胞活化也伴隨著IL-2之製造,因此,本研究 利用貓模式探討貓感染FTV和/或弓蟲後,IL-2及TNF之產量是否會上升。共有四 組,每組四隻三月齡的貓,以人工感染FTV,弓蟲,兩者,或沒感染。結果指出 這四組貓中,在整個實驗期間其淋巴球分泌IL-2的量及在第十四週其淋巴球和巨 噬細胞分泌TNF的量皆沒顯著差異。所有貓隻在第八週後IL-2皆顯著上升,此說 明了貓愈成熟其對疾病抵抗力愈強。總而言之,在本研究實驗條件下,貓感染有 FTV、弓蟲或兩者,其IL-2及TNF產生並沒有變化。因此,像弓蟲這一類之伺機 性病原,如何促使HTV-或FIV感染更加嚴重之機制尚待進一步研究。 |
英文摘要 | Several studies haive suggested that the co-infection with otherpathogens in humans infected with human immunodeficiency virustype 1 (HIV-1) or in cats infected with feline immunodeficiency virus(FIV) may enhance the progression of the disease to acquired immunedeficiency syndrome phase. This enhancement has been thought to bedue to the activation of T cells by co-infective pathogen(s), forexample, Toxoplasma gondii. Activated T cells then produce cellularfactors that bind to both interleukin 2 (IL-2) enhancer elements (kB)and HIV-1 long terminal repeat to initiate transcription of HIV-1mRNA. Because kB-binding factors are induced mainly by tumornecrosis factor (TNF) and IL-2 production is accompanied by T-cellactivation, using feline model, this study was intended to examine ifthere was an increase in the production of IL-2 and TNF in catsinfected with FIV and T. gondii Four groups of cats, four per groupat the age of 3 months old, were used. They were inoculated withFIV and/or T. gondii, or no pathogen. The results showed that therewere no significant differences among four groups of the cats ineither IL-2 production by lymphocytes throughout the study or TXFproduction by both lymphocytes and macrophages at week 14post-infection. The increase in IL-2 production by all groups of thecats after 8 weeks of inoculation may explain that with maturation ofyoung cats their defense to various pathogens is increased. Inconclusion, under present experimental condition, there are no IL-2and TNF changes in cats infected with FIV and/or T. gondii. Themechanisms behind the enhancement of HIV-1 or FIV infection byopportunistic pathogen, like T. gondii, require further investigation. |
本系統中英文摘要資訊取自各篇刊載內容。