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題 名 | Elevated Expression of Epidermal Growth Factor Receptors Mediated by Retinoic Acid in Human Lung Cancer Cells=維生素甲酸對人體肺癌細胞株上皮生長因子受體表現具調節作用 |
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作 者 | 方剛; 施河; | 書刊名 | 師大生物學報 |
卷 期 | 29:1 1994.06[民83.06] |
頁 次 | 頁5-10 |
分類號 | 361.4 |
關鍵詞 | 人類肺癌細胞; 上表生長因子受體; 維生素甲酸; Human lung cancer cells; Epidermal growth factor receptor; Retinoic acid; |
語 文 | 英文(English) |
中文摘要 | 維生素甲酸有調節細胞訊息調節作用。人類肺癌細胞株H460,於維生素甲酸培養下,上皮生長因予受體有增生現像。上皮生長因子受體的表現隨時間而逐漸增加,至48小時為最高,而後開始下降。這種現像可由碘125標示上皮生長因子結合變化,上皮生長因予受體磷酸化變異,及硫35活體標示得知。若將維生素甲酸移去,則增生上皮生長因子受體會維持穩定表現。而所誘導增生上皮生長因子受體也使裸鼠控腫瘤體積增加,也間接談實上皮生長因子受體與腫瘤形成的確有密切關係。這也是首次證明維生素甲酸與蛋白質合成及代謝速率調節有關。 |
英文摘要 | In human lung cancer cell line, H460, an accumulation of epidermal growth factor receptor (EGF-R) was observed following treatment with 1μ.M ofretinoic acid. An increase in 125I-Iabeled EGF binding capacity was detected after 48 h incubation with retinoic acid. Increased autophosphorylation of EGF-R after 48 h treatment of retinoic acid treatment correlates with enhancement of EGF binding capapcity on H460 cell surface. When treated cells were plated in retinoic acid-free medium after 72 h treatment with retinoic acid, EGF-R expression level remained intact. This phenomenon represents a novel EGF-R synthesis on cell surface, induced by retinoic acid. |
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