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題名 | 不同的蛋白質、鈣和磷攝取比率對老年雌鼠骨質流失現象之影響 |
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作者 | 蔡敬民; 黃淑惠; 王克揚; 丁海惠; | 書刊名 | 中華民國營養學會雜誌 |
卷期 | 19:3 1994.07[民83.07] |
頁次 | 頁233-245 |
分類號 | 411.38 |
關鍵詞 | 骨質流失; 蛋白質; 鈣; 磷; Bone loss; Protein; Calcium; Phosphorus; |
語文 | 中文(Chinese) |
中文摘要 | 本實驗的目的在研究飼料中的蛋白質及鈣磷比例對老年雌鼠的骨骼可能造成的影響。實驗將42隻比個月大多產之Long-Evans雌鼠,隨機分配到以NRC建議量(8.4)和3倍NRC建議量(25.2)的二種蛋白質含量,及以鈣;磷分別為NRC:NRC(0.5:0.4),1/3NRC:NRC及1/3NRC:3NRC等3種鈣磷比交叉配成之6種飼料組內,連續餵飼8個月並進行骨骼生理狀態的分析。實驗由骨骼的密度、重量、灰分與鈣、磷含量測定顯示,低鈣高磷且高蛋白的飼料攝取有致使骨骼組成份減少的現象,股骨強度測試與緻密骨厚度的測量結果顯示單就低鈣高磷的飲食亦有致使骨質流失的作用。由股骨切片觀察的結果顯示,幾乎所有的老鼠皆因老化作用的進行而有骨質疏鬆的現象存在,但以長期攝取低鈣高磷飼料的老鼠最為嚴重,蛋白質含量的增加所造成的影響則不明顯。故飼料中鈣量的不足加上磷量的攝取過量曾引發骨質流失的現象,對老年雌鼠的骨骼組織有不良的影響。 |
英文摘要 | The purpose of this study was to investigate the effects of dietary calcium/phosphorus (Ca/P) ratio and protein levels on bone loss in aged rats. Forty twofemale, 12 month old Long-Evans rats were divided randomly into 6 groups. Two protein levels (NRC and 3NRC) and three Ca/P ratios (NRC:NRC, 1/3 NRC:NRC and 1/3 NRC:3 NRC) and a control group were interlaced into 6 different diets for 8 months. The analyzed results of femur density, dry fat-free boneweight, bone ash content, cortical thickness and mineral contents in rats showedthat long term consumption of low calcium, high phosphorus and high proteindiet promoted the rate of bone loss. The low calcium and high phosphorusintake at normal dietary protein level also reduced femur breaking load and cortical thickness significantly. Femur cross section showed that aging was accompained by bone loss, but low calcium and high phosphorus diet induced bone lossmore severely. Increased dietary protein level apparently did not affect bone resorption. This study demonstrated that low calcium intake plus high phosphorus intake might enhance bone loss and destructed bone tissue in aged femalerats. |
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