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頁籤選單縮合
題名 | 氯黴素在禽畜之有效肌肉注射劑量試驗 |
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作者姓名(中文) | 劉朝鑫; 劉雅方; 郭宗甫; 陳雨新; 彭玄桂; | 書刊名 | 國立臺灣大學農學院研究報告 |
卷期 | 34:1 1994.03[民83.03] |
頁次 | 頁87-95 |
分類號 | 437.23 |
關鍵詞 | 氯黴素; 禽畜; 肌肉注射; 劑量; Dosage; Intramuscular injection; Chloramphenicol; Swine; Chicken; |
語文 | 中文(Chinese) |
中文摘要 | 本試驗是以藥物動力學之觀點探求氯黴素貼在肉豬及肉雞肌肉注射投 藥之有效劑量及投藥間隔。氯黴素單次投藥試驗,以50mg/kg b.w.肌肉注射肉豬 後1小時,血清濃度即達高峰,但平均值未達有效制菌濃度5-10μg/ml之範圍。以 40mg/kg b.w.肌肉注射肉雞後4小時,血清濃廣達到高峰,其平均值雖達有效濃度 之範圍,但於投藥後8小時即降低到有效濃度範圍以下。氯黴素重複投藥試驗, 肉豬分三組投藥,各組分別第一次肌肉注射50、60及70mg/kg b.w.,隨後每隔8小 時各肌肉注射半量。試驗結果,使第一次肌肉注射70mg/kg b.w.組之肉豬,能夠 達到並維持有效血清濃度之範圍。肉雞分二組投藥,各組第一次分別肌肉注射40 及5Omg/kg b.w.,隨後每隔8小時各肌肉注射半量,試驗結果,僅第一次肌肉注射 50mg/kg b.w.之肉雞,能夠達到並維持有效血清濃度。從試驗結果明瞭,氯黴素 之肌肉注射投藥之有效劑量及投藥間隔,肉豬及肉雞分別為第一次投藥70及 50mg/kg b.w.,隨後每隔8小時投藥半量。 |
英文摘要 | An attempt was made to determine the intramuscular injectiondosage of chloramphenicol to swine and broiler chicken from the view point of pharmacokinetic study. Chloramphenicol reached thehighest concentration in swine serum after a single IM injection doseof 50 mg/kg b.w., but this concentration was lower than effectiveconcentration. A peak serum level was resulted in 4 hours after asingle IM injection dose of 40 mg/kg b.w. to broiler chicken. Thisserum level was in the range of effective concentration, but itdeclined lower than effective concentration in 8 hours.Administration of 70mg/kg b.w. by IM injection, followed by halfdose every 8 hours could reach and maintain effective serumconcentration of 5-10μ g/ml in swine. In broiler chicken, initial doseof 50mg/kg b.w. followed by half dose every 8 hours, could reach andmaintain effective serum concentration. |
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