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題 名 | 家禽流行性感冒不活化疫苗及佐劑研製之採討 |
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作 者 | 謝快樂; 戴士淵; 沈瑞鴻; 邱新育; | 書刊名 | 臺灣畜牧獸醫學會會報 |
卷 期 | 62 1993.12[民82.12] |
頁 次 | 頁11-20 |
分類號 | 437.245 |
關鍵詞 | 不活化疫苗; 佐劑; 流行性感冒; 研製; 家禽; |
語 文 | 中文(Chinese) |
中文摘要 | 利用本省家禽流行性感冒病毒野外分離株H8N4與其封套表面醣蛋白(HA,NA)作為 疫苗抗原。分別以礦物油(Marcol 52)及植物皂素(saponin ; Quil A)與膽固醇、磷脂質等所 構築而成的ISCOM-免疫刺激複合物(Immuno Stimulating COMplex)作為佐劑,製備單價的油 質乳劑不活疫苗(OE)和ISCOM次單位疫苗。並以血球凝集抑制試驗(Hemagglutination inhibition test ; HI test)血清抗體價作為評估其刺激免疫反應之標準。 在3週齡及5週齡的雞分別以單價的OE和JSCOM免疫注射後,在抗體整體表現上無論是 以OE或是ISCOM免疫皆以5週齡雞的平均HI抗體反應較佳,同時注射OE疫苗所產生的平 均抗體價及其持續性亦較注射ISCOM疫苗者為佳。以ISCOM疫苗補強注射,無論是3週或是 5週齡的雞在補強注射後第1週內ISCOM的抗體爬升率皆較注射OE者為高。 |
英文摘要 | Whole viral particles or envelope glycoproteins of avian influenza virus, H8Ns isolate, were used to prepare oil-emulsion inactivated vaccine (OE) and immunostimulating complex (iscom) subunit vaccine. The immune response of chickens vaccinated with the vaccine was evaluated by means of hemagglutination inhibition test. Vaccines with either kind of adjuvant were subcutaneously inoculated into chickens at 3-week-old or 5-week-old, and revaccinated at 8 weeks after first vaccination. The OE vaccine had better antibody response, in both age groups, not only had higher level of HI antibodies but also maintained the level for longer period of time than the ISCOM vaccine did. Both kinds of vaccines induced better HI antibody response in 5-week-old chickens than in 3-week-okd ones. The ISCOM vaccine had better booster effect than OE vaccine. |
本系統中英文摘要資訊取自各篇刊載內容。