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題名 | The Cellular Basis for Depressed Acquired Immunity in Wasting Protein-Energy Malnutrition:Assessment of Experimental Evidence with Emphasis on Cellular Numbers and Subset Imbalances=消瘦性蛋白質-熱量營養不良時後天性免疫力減弱之細胞學基礎:免疫細胞之數目與種類失衡之實驗證據評析 |
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作者姓名(外文) | Woodward,Bill; | 書刊名 | 中華民國營養學會雜誌 |
卷期 | 19:2 1994.04[民83.04] |
頁次 | 頁101-123 |
分類號 | 415.589 |
關鍵詞 | 消瘦性蛋白質-熱量營養不良; 免疫功能; Wasting protein-energy malnutrition; Immune function; |
語文 | 英文(English) |
中文摘要 | 消瘦性蛋白質-熱量營養不良(PEM)時經常伴隨後天性免疫反應減弱之症狀。這種現象在嬰幼兒與兒童患者最為常見。無論此症狀是原發性或是續發性,兔疫力減弱均使感染性疾病之罹患率與死亡率增加。PEM如何影響免疫功能,在機轉方面的了解還末臻成熟,目前主要的看法以淋巴系統退化與淋巴細胞種類失去平衡為主流;失衡的淋巴細胞是指CD4��(輔助性)與CD8��(抑制性/毒殺性)T細胞。就已知之實驗證據加以評析,顯示現有的看法還可以加以延伸。用離乳期PEM之動物模式,以CD45抗原之同型體為標記,採用表面標記分析法,可證實輔助T細胞(CD4��)與抑制T細胞(CD8��)兩類細胞中細胞亞群(subset)之分佈確有不平衡之現象,與抗原反應力低弱的表現一致。如果只採用表現型分析法則僅能提供功能性的了解。此外,在消瘦型PEM下,學免疫相關的巨噬細胞群也有分佈不均衡的現象。綜而言之,對PEM全身性病理生理之探討中,免疫功能是不可忽略的一環,若能就內分泌激素對淋巴細胞與巨噬細胞功能之調控深入研究,將有助於明瞭免疫細胞亞群分佈失衡與免疫能力低落之機轉。 |
英文摘要 | Depression in acquired immune responsiveness, particularly cell mediatedimmunity, is characteristic of wasting protein-energy malnutrition (PEM) particularly during infancy and childhood. Whether a primary or secondary condition,such PEM-induced immunodepression is generally accepted as increasing the riskof morbidity and mortality from infectious disease. Mechanistic understanding ofimmunodepression in PEM, however, is primitive, Present focus centres onlymphoid involution and lymphocyte subset imbalances, most notably a putativeimbalance between CD4+ (helper/inducer) and CD8+ (suppressor/cytotoxic) T cells,as underlying PEM-associated immunodepression. Critical assessment of availableevidence reveals a need to re-evaluate and to look beyond these widely acceptedideas. Recent surface marker analyses using isoforms of the CD45 antigensuggest subset imbalances consistent with hyporesponsiveness to antigen withinboth the CD4+ and the CD8+ T cell populations in weanling PEM. Phenotypicanalysis, however, can only imply function. Finally, imbalances may also occurwithin accessory cell (macrophage) populations, at least in some forms of wastingPEM. There is great need to incorporate understanding of immune functions intothe systemic pathophsiology of PEM. Study of endocrine hormonal control of lymphoid and accessory cellular functions in PEM may yield important insightsinto the mechanisms underlying cellular subset imbalances and immunodepressionin this disease. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。