頁籤選單縮合
題名 | 氮-氨基-3-芳香基雪梨酮-4-甲醯胺肟的製備及其反應探討 |
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作者姓名(中文) | 施美秀; | 書刊名 | 南臺工商專校學報 |
卷期 | 18 1993.11[民82.11] |
頁次 | 頁67-72 |
分類號 | 461.625 |
關鍵詞 | 腈氧化物; 肟醯氯; 雪梨酮三唑化合物; Nitrile oxides; Hydroximic acid chlorides; Triazolyl sydnone compounds; |
語文 | 中文(Chinese) |
中文摘要 | 3-芳香基雪梨酮-4-甲�艚Q氯化性活潑,且儲存容易,不但能直接與親核試劑作用 ,以合成雜環化合物的前導體,亦可利用反應系中的弱鹼轉變成化性更活潑的�纁韙う哄A再 進行反應。 由於雪梨酮衍生物及一般雜環化合物常具有藥理性質與生理活性, 故本論文以 3- 芳香基雪梨酮 -4- 甲�艚Q氯為起始原料, 先與聯胺水合物作用,生成相對應的氮 - 氨 基 -3- 芳香基雪梨酮 -4- 甲醯胺�瞴A然後在酸的催化下,再與醛類化合物進行環化反應, 以生成一系列含氮量極高的 3- 芳香基 -4- 三唑雜環取代基雪梨酮衍生物, 並期待其具有 生理活性。 |
英文摘要 | Due to having good reactivity and being stored easily, the 3-aryl- sydnone-4-carbohydroximic acid chlorides can directly react with many nucleophilic reagents to produce precursors of heterocyclic compounds. In the presence of base, they also can be converted to the more active nitrile oxides which proceed the rection then. Sydnone derivatives and many heterocyclic compounds are well known to exhibit biological and pharmacological activities. Therefore, in this study, 3-aryl-sydnone-4-carbohydroximic acid chlorides are employed to react with hydrazine to give the corresponding N-amino-3-arylsydnone-4-carbox-amide oximes. Under acid catalyzing condition, the oxime derivatives then cyclize with aldehydes to produce 3-aryl-4-triazolyl sydnones. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。