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頁籤選單縮合
題名 | Candidemia in the Neonatal Intensive Care Unit=新生兒加護中心之念珠菌 血症 |
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作者 | 夏文傑; 遲景上; 王德明; 陳昭惠; | 書刊名 | 中華民國小兒科醫學會雜誌 |
卷期 | 34:5 民82.09-10 |
頁次 | 頁349-355 |
分類號 | 417.517 |
關鍵詞 | 加護中心; 念珠菌血症; 新生兒; |
語文 | 英文(English) |
中文摘要 | 本回溯性研究乃取材自台中榮總新生兒加護中心罹患念珠菌血症之病嬰。時間範圍起於民國七十一年十月以迄八十年十二月,共有十天至六個月大病患十八名,其中男女各九例,並無性別上的差異。本文乃統計並分析彼等之臨床表徵,念珠菌血症之相關因數及其治療過程。新生兒加護中心之念珠菌血症逐年的增加,本研究群中死亡率為56%。十六名病患血中培養出白色念珠菌,而另兩名病患血中則培養出parapsilosis念珠菌。發燒、活力不佳及腹脹為最常見的表徵,使得我們初步臆測為細菌性敗血症及壞死性小腸結腸炎。本文共分析了十一項主要的相關因子,大多與新生兒加護中心之措施及治療有關,諸如長期使用廣效抗生素、全靜脈營養。十八位病患均給予靜注amphotericin B治療,其中六位給於足夠總劑量(>25毫克/公斤),而十二位則不足(3.7±2.9毫克/公斤);十位死亡病例均屬於治療劑量不足者。在加護醫學日益精進的今天,念珠菌血症愈來愈常見,實在是個值得注意的問題。 |
英文摘要 | The hospital records of 18 infants (9 males & 9 females) with one or more positive cultures for Candida species were studied retrospectively in an attempt to define the characteristics, associated factors and treatment for candidemia in the neonatal intensive care unit. The number of patients have increased recently and the mortality rate is 56% (10/18) The Candida species isolated from blood were Candida albicans in 16 cases and Candida parapsilosis in 2 cases. Fever, not-doing-well, and, abdominal distention were the most common presentations, prompting us to the initial impression of bacterial sepsis and/or necrotizing enterocolitis. Eleven associated factors for candidemia were relating to the measures and therapy in the neonatal intensive care unit, such as prolonged use of broad-spectrum antibiotics, parenteral hyperalimentation etc. All of these 18 patients were treated with intravenous amphotericin B. Six patients were given adequate total dose (>25 mg/Kg), while 12 patients underwent inadequate treatment (3.7±2.9 mg/Kg). The 10 fatal patients belonged to the inadequate treatment group. As there is continual progress in neonatal intensive care units, candidemia is becoming an increasing common problem and which deserves attention. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。