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| 題 名 | 兒童隱睪症患者手術時機之探討 |
|---|---|
| 作 者 | 周雪珠; 陳厚全; | 書刊名 | 中華民國外科醫學會雜誌 |
| 卷 期 | 26:2 民82.03-04 |
| 頁 次 | 頁1644-1654 |
| 分類號 | 417.6257 |
| 關鍵詞 | 未降睪丸; Cryptorchidism; Undescended testis or cryptorchid testis; |
| 語 文 | 中文(Chinese) |
| 中文摘要 | 一般常用來評估隱睪症(cryptorchidism)患者其未降睪丸(undescended testis或cryptorchid testis)之組織病理變化或型態異常的方法很多,包括利用光學顯微鏡的檢視比較其與正常睪丸細精管(seminiferous tubule)管徑的大小、精母細胞(spermatogonia)數目的多寡、細精管間膠質纖維組織(interstitial collagen fiber)的增加,及利用電子顯微鏡檢視未降睪丸內部胞器的顯微構造變化,如細胞與細胞之間隙(intercellular space)增加,並有空泡(vacuole)產生,脂褐素(lipofuscin)與髓燐質(myelin)之沉積於賽托利細胞(sertoli cell),以及問質內(interstitium)膠質纖維(collagen fibers)之大量增加等。本研究即是將一歲至十二歲的兒童隱睪症患者,於接受睪丸固定術(orchiopexy或orchidopexy)之際,即施以睪丸活體組織切片檢查,再利用光學及電子顯微鏡檢查,細觀其組織學上之變化並與正常下降之睪丸(descended testis or scrotal testis)做一比較。由我們的臨床研究結呆顯示不論是由光學或電于顯微鏡的檢視,發現在一歲半以後的未降睪丸即有很顯著的退行性變化,且年齡愈大其退化之程度也愈大。因此,我們建議兒童隱睪症患者的適當手術年齡應由以往所認為的五、六歲提前到一歲半左右,且最遲不應晚於兩歲。 |
| 英文摘要 | There are many methods to evaluate histopathologic or morphologic changes in undescended testes in cryptorchidism. These include comparing the diameter of the seminiferous tubule or mean tubular diameter and the number of spermatogonia with those in the descended testis, using light microscopy as well as observing ultrastructural organelles of cryptorchid testis using electron microscope. Electron microscopic examinations include the width of the intercellular space, the generation of vacuoles, the deposition of lipofuscin and myelin in Sertoli cells, and the great number of collagen fibers. Testicular biopsy specimens were obtained during orchidopexy from patients between 1 and 12 years of age. These specimens were compared with the normal testis of patients at the. same ages not only by light microscopic but also by electron microscopic examination. Findings showed that there were some significant retrograde histopathologic changes in cryptorchidism after one and half years of age, and, the older the patients, the more dysgenetic the morphology. These findings persuade that orchidopexy should be performed early in children, at about one-and-half years and no later than two, rather than at five to six years old, as was thought earlier. |
本系統中英文摘要資訊取自各篇刊載內容。