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題名 | 翼狀贅肉手術後使用不同濃度及不同點藥頻率Mitomycin C的比較 |
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作者 | 顏忠信; 李尚儒; 曾順輝; | 書刊名 | 中華民國眼科醫學會雜誌 |
卷期 | 31:3 1992.09[民81.09] |
頁次 | 頁18-24 |
分類號 | 416.741 |
關鍵詞 | 翼狀贅肉手術; 眼疾; Pterygium; Mitomycin C; Bare sclera; |
語文 | 中文(Chinese) |
中文摘要 | 自民國80年2月至民國81年5月間收集156個初發性翼狀贅肉病例,以前 瞻式分組,對翼狀贅肉切除術後施以不同濃度及不同頻率Mitomycin C之再發及併 發症做一評估。所有病例由同一手術小組施以鞏膜裸露術後,第一組給予0.04 Mitomycin C藥水滴眼,Qid使用,第二組給予0.04 Mitomycin C,Bid,第三組給予 0.02Mitomycin C,Qid,第四組給予0.02Mitomycin C,Bid。所有藥物均持續一星期治 療。各例記錄施藥前後一星期眼壓變化及病人自覺之不適感。術後追蹤三個月以 上,凡有新生血管犯及角膜即視同再發。結果第一組37例中有3例再發(8.1),第 二組38例中有4例再發(10.5),第三組41例中有4例再發(9.8),第四組40例中有7例 再發 (17.5)。四組再發率雖有差異,但無統計上的意義(P>0.05)。點藥前後之眼壓 變化四組之間亦無統計上的差別(P>0.05)。但是0.04二組病人主觀的不適感明顯地 大於0.02二組。0.04 Qid組有一病例發生細菌性鞏膜潰瘍,0.04二組各有一病例發 生肉芽腫。由此使用0.02 Mitomycin C在預防翼狀贅肉復發上復發率無意義差別於 0.04 Mitomycin C,但刺激性較小且較安全。點藥頻率較少的0.02 Bid組在刺激性 及復發率與0.02Qid組均無統計上差異(P>0.05),因此,0.02 Mitomycin C Bid對於翳 狀贅肉手術輔助治療,為一安全而方便的選擇。 |
英文摘要 | A prospective study of 156 eyes for evaluatingthe preventive therapy of primary pterygium recur-rence, the side effects and the complications of dif-ferent dosages of Mitomycin C. All pterygia were excised by Bare sclera technique and by the samegroup. The postoperative remedies were divided into four groups: the first contained 37 eyes and were treated with 0.04 Mitomycin C qid, the secondgroup contained 38 eyes and were treated witli 0.04Mitomycin C bid, the third group contained 41 eyes and treated with 0.02 Mitomycin C qid, and the last group contained 40 eyes which received 0.02Mitomycin C bid. All cases received therapy for one week and were followed up for 3 months. In-traocular pressure before and after therapy and the subjective discomfort by each patient were well documented. Recurrence was defined as the neovascularized tissure invaded the limbus again, The recurrent rates were 8.1 (3/37), 10.5(4/38), 9.8(4/41) and 17.5(7/40) for each following group. No statistic significance was noted among the four groups(p>0.05). There were also no significant differences of intraocular pressure change among the four groups(p>0.05). However, marked subjective discomfort were noted in the 0.04 groups. Besides, one bacterial scleral ulcer was found in the 0.04 qid group, and two cases of granulation formation were noted in each 0.04 group. The authors believe that 0.02 Mitomycin CBid is a safe and effective adjunct to surgical excision in the treatment of primary pterygium. |
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