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題名 | Auditory Brainstem Responses in Term Neonates Treated with Gentamicin=用Gentamicin治療的足月新生兒其聽覺腦幹誘發電位的變化 |
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作 者 | 蔡長海; 蔡輔仁; | 書刊名 | 中華民國小兒科醫學會雜誌 |
卷期 | 33:6 民81.11-12 |
頁次 | 頁417-422 |
分類號 | 417.5012 |
關鍵詞 | 足月; 治療; 新生兒; 腦幹; 電位; 誘發; 聽覺; |
語文 | 英文(English) |
中文摘要 | 我們利用聽覺腦幹誘發電位(ABR)檢查了17個因長期破水或母親發燒而接受gentamicin治療的新生兒,並和27個體重相近的新生兒作比照。治療組新生兒接受2.5mg/kg的gentamicin每天兩次,gentamicin的血清濃度分別在第5個劑量給予後30分鐘及第6個劑量給予前30分鐘測得,ABR的檢查則在出生第3天及第10天實施。結果顯示第三天測得ABR在第V波,第I-V第Ⅲ-Ⅴ波間潛時皆有延遲現象,但在第10天追蹤時自行恢復。由以上的結果發現即使短期使用gentamicin亦會影響ABR,雖然其變化會自行恢復但對新生兒使用gentamicin有要小心謹慎。 |
英文摘要 | Seventeen infants who had been treated with gentamicin on the first day of life as prophylaxis for prolonged rupture of membranes or maternal fever. Twenty-seven weight-matched healthy infants were used as controls. The auditory brainstem responses were evaluated on the third day and again on the tenth day of life. Latencies of components V, intervals I-V and Ⅲ-Ⅴ were significantly prolonged in the gentamicin treated group when compared with the control group. This prolonged latencies reversed itself on the tenth day of life. The concentration of peak and trough levels of gentamicion were relate to latency of interval Ⅲ-Ⅴ. These finding emphasize that a short course therapy with gentamicin in essentially healthy infants can alter the central transmission of auditory brainstem responses transiently. |
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