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題 名 | Inward Rectifier and Delayed Outward Potassium Currents in Isolated Guinea-Pig Ventricular Myocytes:Maturation and Its Role in Repolarization=分離天竺鼠心室細胞之內向整流及遲發性外向鉀電流之成熟以及其再極化角色 |
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作 者 | 吳美環; 蘇銘嘉; 呂鴻基; | 書刊名 | 中華民國小兒科醫學會雜誌 |
卷 期 | 33:5 民81.09-10 |
頁 次 | 頁363-371 |
分類號 | 417.5212 |
關鍵詞 | 內向; 分離; 天竺鼠; 心室; 外向; 細胞; 鉀; 電流; 整流; 遲發性; |
語 文 | 英文(English) |
中文摘要 | 由分離之單一天竺鼠心室細胞誘發的動作電位顯示,成熟天竺鼠(>1個月)的動作電位期間顯著地長於新生天竺鼠。我們利用全細胞單一吮吸電極電壓鉗定法測定其內向整流鉀電流(I[K1])與遲發性外向鉀電流(I[K]),以協助了解I[K],與I[K]的成熟化及其與動作電位期間演變的關係。由動物行為來看,新生天竺鼠的成熟度遠超過新生鼠或白兔,而I[K1]的內向整流性質及其斜率導電度在新生及成熟的天竺鼠細胞之間並無顯著差異。然而I[K]的斜度導電度卻隨著成熟而漸減(新生天竺鼠,702±80 pS/pF,n=10,成熟天竺鼠,194±23 pS/pF,n=10,p<0.01)。相形之下,對於再極化過程的貢獻,I[K]隨著成熟而漸減,而I[K1]則漸增。這假設也由所謂移動梯似電壓鉗定法得到證實。我們的結論為(l)心室細胞I[K]的成熟過程較I[K1]出現的晚,(2)新生動物心室細胞較大的I[K]斜率導電度,能導致其動作電位期間的縮短。 |
英文摘要 | In accord with previous reports, we have found that action potentials triggered from isolated mature (>1 month) guinea-pig ventricular myocytes showed a longer duration than those from the neonate (<1 day). A whole-cell voltage-clamp technique has been used to identify the postnatal changes of inward rectifier (I[K1]) and delayed outward potassium currents (I[k]) which may be related to the action potential transition. Our results have shown that the degree of maturation of the neonatal guinea-pig is much advanced, as compared to neonatal rabbits and rats. Slope conductance (1230±110 pS/pF, n=10, for neonatal, and 1450±450 pS/pF, n=l0, for mature guinea-pig, p>0.05) and the inward rectification occurring over a potential range from -50 to -10mV were relatively similar between the neonatal and mature guinea-pig myocytes. But, the slope conductance of I[k] was significantly greater in neonatal (702±80 pS/pF, n=10) guinea-pig myocytes than in the mature (194±23 pS/pF, n=10, p<0.0l). Therefore, we suggest that (1) the maturation of I[k] appears later than that of I[k] (2) age-related decrease of the slope conductance of I[k] could contribute to an age- related lengthening of the action potential duration. |
本系統中英文摘要資訊取自各篇刊載內容。