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題 名 | 人體藥物參數值尋求最佳室體模式之研究 |
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作 者 | 王又英; 陸海林; | 書刊名 | 嘉南學報 |
卷 期 | 18 1992.11[民81.11] |
頁 次 | 頁44-52 |
分類號 | 418.1 |
關鍵詞 | 人體; 參數值; 藥物; |
語 文 | 中文(Chinese) |
中文摘要 | 在藥物動力學(pharmacokinetics)上,我們對藥物投入人體中,通過吸收、 分佈、代謝及排泄等速率過程,應屬於何種室體模式(compartment body model), 這些不同室體模式伴隨著不同的係數值,而近些係數值對藥物在體內動態有甚為 重要的描述,故求出適當的模式為本文目的。 本文以數值例對三種室體,及藥物中動差(Moment)性質各別加以求出之0-階、1- 階、2-階動差,做比較,求出較適合之室體模式,以做藥物動力學參數求值之基 準。 |
英文摘要 | In phannacokinetics, when drug dosage is appliced to human body, which compartment bodymodel does the dosage go to by the process of absorption, distribution, biotransformation and excreation? "Those difTerent compartment body models are accompanied with different coefficientvalue which has a very important influence on parameter of drug dosage. The parameter value ofphannacokinetics contributes to a description of the development of drug in physical body. Theresearch is aimed at finding out the proper model. On the basis of three compartment body models and statistical Moment of drug dosage, wecan work out the O-Factorial ' 1-Factorial and 2-Factorial. We may find out the appropriatecompartment body model which can be used as a rule of the parameter value of phannacokinetics. |
本系統中英文摘要資訊取自各篇刊載內容。