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| 題 名 | Cytomegalovirus-Associated Neonatal Hepatitis=與巨細胞病毒有關之新生兒肝炎 |
|---|---|
| 作 者 | 賴明瑋; | 書刊名 | 中華民國小兒科醫學會雜誌 |
| 卷 期 | 33:4 民81.07-08 |
| 頁 次 | 頁264-272 |
| 分類號 | 417.5167 |
| 關鍵詞 | 巨細胞; 肝炎; 病毒; 新生兒; |
| 語 文 | 英文(English) |
| 中文摘要 | 五十五位罹患與巨細胞病毒(Cytomegalovirus)有關之新生兒肝炎患者在追蹤十二到九十個月後,六位病人(10.9%)死於猛爆性肝衰竭或慢性肝臟疾病。其餘四十九位病人,則肝功能完全復原,但是其中8位出現生長發育之遲滯,2位出現聽力障礙;亦即百分之二十點四的存活者深受巨細胞病毒感染之長期影響。預後不良的決定因子包括:在臨床徵狀方面有持續性的灰白便,脾腫大,腹水、或貧血;在實驗數據方面有偏高之總膽紅素(≧15mg/dl),直接膽紅素(≧10mg/dl),或偏低之白蛋白(<3.0gm組1);在病理組織方面有厲害之彌漫性巨細胞變形及肝硬化。巨細胞病毒抗體之陽性率和預後之關係則不顯著。 |
| 英文摘要 | Fifty-five with cytomegalovirus (CMV) -associated neonatal hepatitis (NH) were followed for 12 to 90 months. Six patients (10.9%) died from either a fulminant course or a chronic liver disease. Among the remaining 49 patients, whose liver function was completely recovered, there were eight with retardation of developmental or growth status, and two with hearing impairment. Overall, 20.4% of the survivors suffered from a long-term impact. The unfavorable outcome was related to several clinical and pathological parameters. These included persistence of clay-colored stool, presence of splenomegaly, ascites or anemia, high peak total and direct bilirubin, low nadir albumin levels, diffuse giant cell transformation and cirrhosis of the liver. The seropositivity of CMV infection did not significantly correlate with the outcome. |
本系統中英文摘要資訊取自各篇刊載內容。