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- Defective Response of Plasma Growth Hormone the Growth Hormone Releasing Factor in Growth Hormone Deficient Children
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題名 | Defective Response of Plasma Growth Hormone the Growth Hormone Releasing Factor in Growth Hormone Deficient Children=生長激素缺乏症兒童的生長激素對生長素釋素之反應不全 |
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作者姓名(中文) | 柯芳圓; 陳偉鵬; 林清淵; | 書刊名 | 中華民國小兒科醫學會雜誌 |
卷期 | 33:4 民81.07-08 |
頁次 | 頁243-250 |
分類號 | 417.5933 |
關鍵詞 | 生長素; 生長激素; 兒童; 缺乏症; 釋素; |
語文 | 英文(English) |
中文摘要 | 為了解血漿生長激素對生長素釋素(GRF(1-29)NH2)的反應並建立國人之參考值,5位身高正常的兒童和14位原發性生長激素缺乏症兒童接受了每公斤一微克(lμg)生長素釋素(GRF(l-29)NH2)的靜脈注射且於注射前(0分)及注射後15, 30, 45, 60, 90, 120公鐘測其血漿生長激素濃度。結果如下:一、在身高矮小的正常兒童,每人的血漿生長激素於注射後45分鐘達到最高值(80.31±19.28ng/ml)。二、大多數的生長激素缺乏症兒童也在注射後45分鐘達最高值(13.10±10.78ng/ml),與身高矮小的正常兒童相比較則顯著降低(P<0.01)。比較生長素釋素及胰島素誘發低血糖試驗對生長激素缺乏症兒童之血漿生長激素最大釋出量,發現似乎對生長素釋素反應高者在胰島素誘發低血糖試驗亦誘發較高之生長激素,但統計上並無有意義之相關。注射生長素釋素後的最高生長激素值和其年齡或骨年齡亦無有意義之相關。三、14位生長激素缺乏症兒童中有3位(佔21.4%)對生長素釋素GRF(l-29)NH2有大約半值的反應。因此推測其生長激素缺乏的病變可能在於下視丘。總結,生長素釋素試驗是鑑別診斷生長激素缺乏症有效且安全的方法之一,並且將來此藥劑或可應用於病灶在下視丘患者之治療。 |
英文摘要 | In an attempt to establish the reference pattern and the plasma growth hormone (GH) response to growth hormone releasing factor (GRF) (1-29)NH2, 5 normal stature with single kidney children and 14 with idiopathic GH deficient dwarfism received intravenous injections of 1μg/kg GRF(1-29)NH2. Plasma Gil levels were measured at 0, 15, 30, 45, 60, 90, and 120mm after injection. The results showed that, first, in normal stature with single kidney children, each plasma GH reached peak level (80.31±19.28ng/ml) at 45mm after injection. Second, the majority of those with GH deficient dwarfism also obtained maximal GH levels (13.10±10.78ng/ml) at 45mm after injection but at significantly lower levels than the normal children (P<0.01). To compare with that obtained after the insulin-induced hypoglycemia test, the peak GH level after GRF was higher but there was no significant correlation between them. The maximal GH level after GRF (1-29)NH2 injection did not show significant correlation with either chronological age or bone age. Third, 3 of 14 (21.4%) with Gil deficient dwarfism had half response to GRF (1-29)NH2. It is reasonable to assume that out of these patients' Gil deficiency is of hypothalamic origin. Therefore, GRF test is a safe and useful test for differential diagnosis of defect level in Gil deficiency and may become a therapeutic regimen. |
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