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| 題 名 | The Local Effect of Garlic Instillation on Normal Rat Bladder: A Preliminary Report=局部灌注蒜汁對正常老鼠膀胱之影響: 初步研究報告 |
|---|---|
| 作 者 | 于大維; 張聖原; 馬正平; | 書刊名 | 醫學研究 |
| 卷 期 | 12:1 1991.07[民80.07] |
| 頁 次 | 頁33-42 |
| 分類號 | 415.121 |
| 關鍵詞 | 正常; 老鼠; 局部; 膀胱; 蒜汁; 影響; 灌注; |
| 語 文 | 英文(English) |
| 中文摘要 | 膀胱內灌注蒜汁已逐漸蔚為一表淺性膀胱癌免疫化學治療之模式。本計劃著重於能事先測得同時可對癌細胞達到最大毒殺作用而且正常膀胱所能忍受之適當劑量。在一次灌注100%大蒜汁之急性期整層膀胱壁可看到明顯之充血、水腫及肌肉層溶解。經過六次重覆灌注後可看到黏膜下層纖維化。除了在長期灌注後可見黏膜下層纖有輕度多核炎性細胞及淋巴球侵潤外,使用10%及20%之大蒜汁灌注之肺胱並無明顯變化。此研究之結果將可提供日後使用蒜汁治療青淺性膀胱癌之參考。 |
| 英文摘要 | Garlic instillation of the urinary bladder is becoming a part of immunochemotherapeutic modalities for superficial bladder cancer. The tolerable dosage of garlic extract on normal bladder with lowest side effects and with maximal cytotoxicity on tumor cells was our concern in this study, since we proved the cytotoxicity effect of garlic extract on cultured bladder cancer cells. Severe congestion hemorrhage, edematous change of the whole bladder wall and muscular lysis were seen in one shot off 100% garlic extract instillation. Submucosal and muscular fibrosis with contracture of the bladder was noted after repeated treatment (six times weekly) with 10% and 20% garlic extracts repeat instillation, there were no prominent side effects except submucosal infiltration of polymorphonuclear cells and lymphocytes. There were no severe sloughing of mucosa, submucosal edema, congestion or hemorrhage, or muscular lysis and fibrosis in either group. These results suggested that 10%-20% garlic extract was acceptable as the therapeutic concentration for future intravesical application in superficial bladder candder cancer treatment, since the side effects were low and cytotoxic efficacy on tumor cells is high. |
本系統中英文摘要資訊取自各篇刊載內容。