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- 具症狀性存開性動脈導管之早產兒以indomethacin藥物治療
- Indomethacin for the prevention of symptomatic patent ductus arteriosus in very low birth weight infants
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| 題 名 | 具症狀性存開性動脈導管之早產兒以indomethacin藥物治療 |
|---|---|
| 作 者 | 何文佑; 黃富源; 高信安; | 書刊名 | 中華民國小兒科醫學會雜誌 |
| 卷 期 | 32:2 民80.03-04 |
| 頁 次 | 頁88-94 |
| 分類號 | 417.5171 |
| 關鍵詞 | 症狀性存開性動脈導管; 早產兒; indomethacin; |
| 語 文 | 中文(Chinese) |
| 中文摘要 | 早產兒,當經由存開性動脈導管的左至右分流足以影響其心肺功能時,臨床內稱為具症狀性存開性動脈導管。目前被公認的觀念就是一個嬰兒,尤其是正在依賴器械輔助呼吸的早產兒,其具症狀性存開性動脈導管,如不加以治療,將明顯地增加嬰兒的成病率和死亡率,故應以藥物或行外科手術使之關閉。由1984年11月至1987年7月,我們共有22例具症狀性存開性動脈導管之早產兒,接受了經由胃管灌食0.1-0.5mg/dose l-3劑為一治療程之indomethacin治療,成功率為68%。由1987年12月至1989年6月,我們再度選擇了33病例,作為indomethacin療效的評估,為了避免將藥片壓碎的劑量難以計算和沈澱問題,遂將indomethacin溶於酒精,製成0.1mg/ml之溶液,給予0.1-0.3mg/Kg/dose 1-3劑為一治療程,成功率亦僅70%。我們獲得的結果是indomethacin的療效,內服劑不如靜脈注射劑,但在未能取得靜脈注射劑之前,將藥片製成溶液,亦是可用之藥物療法。 |
| 英文摘要 | When left to right shunting through the ductus arteriosus is of a degree contributing to the cardiopulmonary problems in a premature infant, the condition is clinically termed symptomatic PDA. It is also generally agreed that symptomatic PDA if left untreated is a significant cause of increased morbidity and mortality. Studies have also concluded that all infants with symptomatic PDA who are prematurely born and/or ventilator dependent should be considered candidates for ductal closure by either pharmaclogical or surgical mean. Over a period of approximately 2 1/2 years, 22 premature infants with symptomatic PDA have been treated here with powder form indomethacin. The one course success srate was 68%. Thereafter, in another 2 1/2 years, 33 cases were selected for whom a liquid form was used instead. The success rate was 70%. Indomethacin is better given by an intravenous route. However, if the intravenous form is not available, using the liquid form by mouth or via the naso-gastric tube is a good substitute. |
本系統中英文摘要資訊取自各篇刊載內容。