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頁籤選單縮合
題名 | The β-Lactam Antibiotic Resistance of E. coli Isolated From Clinic=臨床之大腸桿菌對β-Lactam 類抗生素抗藥性之研究 |
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作者 | 李雪煇; |
期刊 | 醫學研究 |
出版日期 | 19890700 |
卷期 | 10:1 1989.07[民78.07] |
頁次 | 頁17-24 |
分類號 | 414.85 |
語文 | eng |
關鍵詞 | 大腸桿菌; 抗生素; 抗藥性; 研究; 臨床; |
中文摘要 | 由三軍總醫院分離的102株大腸桿菌中發現有76.5%(78/102)是屬於Ampicillin抗藥性表現型菌株。若以β-lactamase試紙偵測法檢測上述抗藥性表現型菌株時,有97.4%(76/78)是呈陽性之酶活性反應,且這其中有76.3%(58/78)可經由菌落DNA雜交法測知含有TEM-1或TEM-2 β-lactamase之基因。有兩株Ampicillin抗藥性表現型菌株不產生β-lactamase,其可能由其他抗藥機轉逃避Ampicillin之毒殺。在102株菌中僅發現一株具有盤尼西林醯酶活性,但此菌株卻對Ampicillin敏感,此事實顯示某些細菌雖可以盤尼西林醯酶切除β-lactam類抗生素之側鏈結構但卻未能對該類抗生素產生抗藥性。由尿液檢體所得之33株大腸桿菌中,有70%(23/33)是屬於Ampicillin抗藥性表現型,其中96%(22/23)可產生β-lactamase但僅68.2%(15/22)菌株帶有TEM-1或TEM-2 β-lactamase基因。此事實指出除了TEM-1和TEM-2之β-lactamase基因可負責合成β-lactamase外,可能尚有其他基因也能合成β-lactamase基因。 |
英文摘要 | Of 102 Escherichia coli isolates obtained from the Tri-Service general hospital in Taipei, 76.5% (78/102) were found to be resistant to ampicillin. Among the said ampicillin-resistant isolates, 97.4% (76/78) were found to show β-lactamase activity, as detected by the method ofβ-lactamase detection papers, and 76.3% (58/76) ofβ-lactamase producing E. coli isolates were found to possess the TEM-1or TEM-2 β-lactamase gene when examined by colony hybridization. However, there were two (about 2%) ampicillin-resistant isolates possessing no β-lactamase activity. These two isolates might somehow escape the killing action of β-lactam antibiotics by other means. There was only one (about 1%) isolate which reflected the penicillin acylase activity but was sensitive to ampicillin, indicating that penicillin acylase might play a negligible role in the resistance to β-lactam antibiotics. Of 33 E. coli isolates which were sourced from urine specimen, about 70% (23/33) were found to be ampicillin resistant, and 96% 22/23) of them showed β-lactamase activity. However, only 68.2% (15/22) of the β-lactamase producing strains contained TEM-1or TEM-2 β-lactamase gene. |
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