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題名 | Pretreatment serum cholesterol level as a prognostic indicator in infants and children with hepatoblastoma=治療前血清膽固醇值可為嬰兒及兒童肝芽細胞癌之預後指標 |
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作者姓名(中文) | 劉曉俊; | 書刊名 | 中華民國小兒科醫學會雜誌 |
卷期 | 29:4 民77.07-08 |
頁次 | 頁254-260 |
分類號 | 417.62451 |
關鍵詞 | 血清膽固醇值; 嬰兒; 兒童; 肝芽細胞癌; |
語文 | 英文(English) |
中文摘要 | 為明瞭血清膽固醇值在嬰兒及兒童肝芽細胞癌預後上的價值,乃對19位病童做此研究。4位病童有正常的冶療前血清膽固醇值(105-160mg/dl)。他們均做了右葉肝臟切除術,有2位病童並且接受術後化學治療。所有4位病童術後至今仍存活3年至16年。3位病童有治療前輕膽固醇血症(254-267mg/dl)。其中2位病童因腫瘤侵犯肝左右兩葉而無法手術切除,他們分別在1個月及7個月後死亡。另外1位病童做了右葉肝切除術後目前已存活了4年。12位病童有重度高膽固醇血症(300-680mg/dl)。其中7位病童因腫瘤侵犯肝左右兩葉或發生轉移而無法手術切除。除了最近的1例尚未死亡外,其餘6位病童均在1周至4個月內死亡。有5位病童接受手術切除腫瘤,其中4位分別在術後1天至1年10個月內死亡。另外1位病童最近順利切除右葉腫瘤並接受化學治療,目前仍存活且無腫瘤復發跡象。長期存活病例的治療前血清膽固醇的平均值為160.40±63.0gmg/dl (n=5),與死亡例的治療前血清膽固醇的平均值354.50±112.10mg/dl (n=12)比較,呈有意義的低下(p<0.005)。由以上的研究結果,我們認為治療前血清膽固醇值可為嬰兒及兒童肝芽細胞癌之預後指標。 |
英文摘要 | The prognostic value of serum cholesterol level was studied in 19 infants and children with hepatoblastoma. Four patients had a normal pretreatment serum cholesterol level (105-160mg/dl). All the 4 patients underwent hepatic resection and are alive now with a long term survival of 3 years to 16 years. Three patients had borderline high serum cholesterol level (254-267mg/dl). Two of these 3 patients had unresectable tumors involving both lobes and died 1 month and 7 months later, respectively. Another patient underwent right lobectomy and has been well for 4 years to the present. Twelve patients had a high serum cholesterol level (300-680mg/dl). Seven of them had tumor involving both lobes or metastasis and were considered unresectable at presentation. They all died 1 week to 4 months later, except for a recent patient who is still alive but has unresectable tumor involving both lobes. Five patients underwent hepatic resection with fatal outcome in four, 1 day to 1 year and 10 months after operation. The remaining patient is currently postoperative for 2 months. The mean cholesterol level in the long term survival group was 160.40±53.09mg/dl (n=5), significantly lower than in the fatal group 354.50±112.10mg/dl (n=12) (p<0.005). These data suggest that pretreatment serum cholesterol level may serve as a prognostic indicator in patients with hepatoblastoma. |
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