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題 名 | 過敏性氣喘及系統性狼瘡性紅斑病兒血清型干擾素及其抗體之研究 |
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作 者 | 劉文章; | 書刊名 | 中華民國小兒科醫學會雜誌 |
卷 期 | 29:3 民77.05-06 |
頁 次 | 頁159-166 |
分類號 | 417.5343 |
關鍵詞 | 干擾素; 血清型; 抗體; 系統性; 研究; 紅斑; 氣喘; 狼瘡性; 病兒; 過敏性; |
語 文 | 中文(Chinese) |
中文摘要 | 本研究的目的乃探討型干擾素(α-IFN)及型干擾素抗體(α-IFNAb)與過敏性氣喘及系統性狼瘡紅斑之關係。15名呼吸道感染病兒,53名過敏性氣喘病兒包括31名初診及22名經減敏治療1年以上的病兒,20名經治療而呈不活動期之系統性狼瘡紅斑病人及22名健康兒,總共110名均抽血檢查α-IFN及α-IFNAb,並與IgE值或C3及IgG濃度相比較。α-IFN乃以放射性免疫分析法(RIA)而α-IFNAb乃以酵素免疫分析法(EIA)加以檢查。呼吸道感染羣有8名(53.3%),系統性狼瘡紅斑有8名(40.0%),氣喘初診羣有10名(32.3%),氣喘治療羣有5名(22.7%)可測得-αIFN,而健康兒均不可測得,除氣喘治療羣外,其他各羣α-IFN與健康兒羣相比較均呈有意羲之升高(p<0.005,p<0.005及p<0.01)。而α-IFNAb卻只在氣喘初診羣中有3名呈陽性,其濃度也低而其α-IFN也不可測出,病兒之IgE亦低,臨床症狀也較輕。過敏性氣喘病兒如可測出α-IFN則IgE值較高。系統性狼瘡紅斑如可測出α-IFN則C3值較低而IgG值較高。可見α-IFN與上述疾病之活性有關,而α-IFNAb則似乎於氣喘有益。 |
英文摘要 | The purpose of this study was to determine the a-interferon (α-TFN) and α-interferon antibodies (α-IFN Ab) in allergic bronchial asthma and systemic lupus erythematosus (SLE) and their correlation to the disease activity. Sera from 22 healthy and 15 respiratory tract infection children were used as controls, twenty sera from inactive stage SLE, fifty-three sera from thirty-one newly diagnosed and twenty-two well treated asthmatic patients were studied. The α-IFN was determined with RIA (Sucrospe; Boots-Celltech Diagnostics Ltd, UK) and α-TFN Ab with EIA (ANAWA Laboratorien AG Switzerland). Serum α-IFN was detected in 53.3% (8/15) of respiratory tract infection, 40.0% (8/20) of SLE, 32.3% (10/31) of newly diagnosed and 22.7% (5/22) of well treated asthmatics. By contrast, it was undetectable in all healthy children. Serumα-IFN Ab was detected in 9.6% (3/31) of newly diagnosesd asthmatics only. The possible role of α-IFN and α-IFN Ab in the pathogenesis of allergic bronchial asthma and SLE has been discussed. |
本系統中英文摘要資訊取自各篇刊載內容。