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題名 | Postoperative Pain Relief with the Synergistic Interaction of Epidural Clonidine and Nalbuphine=硬腦膜外腔施予Nalbuphine及Clonidine 以緩解術後疼痛 |
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作 者 | 王志中; | 書刊名 | 中華民國外科醫學會雜誌 |
卷期 | 21:5 1988.09[民77.09] |
頁次 | 頁540-547 |
分類號 | 416.5 |
關鍵詞 | 疼痛緩解; 硬腦膜外腔; |
語文 | 英文(English) |
中文摘要 | 本研究之目的乃在探討硬腦膜外腔施予clonidine, nalbuphine或合併使用時所生之止痛效果。 共有45位接受上腹部手術之病患,依抽籤方式分為三組,每組20人。第一組給予clonidine 75 ug,第二組給予nalbuphine 10 mg,第三組給予clonidine 75 ug +nalbuphine 10 mg。三組之藥物皆配製於生理鹽水中達10 ml,經硬腦膜外腔給予病患,以緩解嚴重術後疼痛。 止痛作用開始時間,第一組為45分鐘,第二組為10分鐘,第三組為5分鐘。止痛持續時間,第一組為5小時,第二組為6小時,第三組為7小時。就止痛強度而言,第一組僅有輕微之止痛作用,第二組為中度之止痛效果,第三組為強效且快速之止痛效果。 合併使用clonidine及nalbuphine於硬腦膜外腔中可產生強效且快速的止痛作用。 |
英文摘要 | The aim of our clinical trial was to evaluate the analgesic effect of epidural nalliuphine, alone and in combination with clonidine, on acute postoperative pain. 75 μug of clonidine was given to a series of 20 patients (Gr.l) for postoperative pain relief, after upper abdominal surgery. Nalbuphine 10 mg was given to another 20 patients (Gr.2), and a third series (Gr.3) of 20 patients received the combination of 10 mg of nalbuphine and 75μg of clonidine epidurally. Time of onset of analgesic effect in Gr. 1 was 45 min., in Gr.2 10 min., and in Gr.3 5 min., Duration of this effect was 5 hrs. in Gr.l, 6 hrs. in Gr.2, and 7 hrs. in Gr.3. A rapid onset and potent analgesic effect was observed in Gr.3 in comparison with Gr.l and Gr.2. The synergistic interaction of epidural clonidine and nalbuphine produces a potent and adequate analgesic effect on acute postoperative pain. |
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