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題 名 | 中藥及干擾素治療C型肝炎之評估=The Efficacy of Chinese Herbs and α-Interferon Combination Therapy for Hepatitis C |
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作 者 | 鄭庚申; 黃進明; 李純青; 湯惠玲; 莊榮豐; | 書刊名 | 中國醫藥雜誌 |
卷 期 | 2:1 1997.03[民86.03] |
頁 次 | 頁33-36 |
分類號 | 413.34 |
關鍵詞 | 聚合酶鏈反應; 干擾素; 中藥; P.C.R.; Interferon; Chinese herbs; |
語 文 | 中文(Chinese) |
中文摘要 | 以干擾素治療慢性C型肝炎病人,約只有15%∼25%之病人在停藥後有長期的肝功能正常,不甚理想。本研究以α-干擾素、中藥、α-干擾素加中藥合併療法三種治療方式來探討改進療效,並以PCR(Roche Amplicor TM monitor HCV)來追蹤治療後血清HCVRNA濃度之改變情形。共有12例經酵素免疫分析法測定血清 HCVAb 陽性,肝功能 ALT 或AST 值持續不正常超過六個月,臨床及腹部超音波無明顯肝硬化徵象者進入此研究。男性9人,女生3人,平均年齡為45歲,這些病人依其本身治療意願分成三組:A組接受α-干擾素治療,B組接受本院中藥治療,C組為�隊z擾素加中藥的合併療法。三者皆接受完整六個月之治療,其中A組病人在治療結束時,ALT轉為正常者有二人,HCV RNA檢測一人呈陰性反應三人明顯降低;B組僅接受中藥治療者肝功能ALT及HCV RNA皆無降低之趨勢;C組合併中藥及干擾素治療則有二人肝功能ALT及HCV RNA已呈陰性,而副作用在C組病人有減輕之現象。本研究初步結果顯示:慢性C肝炎對α-干擾素及中藥合併療法的反應率,比起單用α-干擾素及單用中藥有顯著的增加且副作用低。 |
英文摘要 | Only 15-25% patients who received α-interferon therapy for chronic hepatitis C had long term normalization of liver function after completion of therapy. The clinical efficacy of three different regimens:(1) α-interferon; (2) Chinese herbs; and (3) α-interferon plus Chinese herbs were evaluated. PCR Roche Amplicor monitor HCV) was used only to monitor changes in HCV RNA concentration after treatment. Twelve patients who had HCVAb positive (EIA method), continuously abnormal serum liver function test ALT or AST level over a 6 month period, and no significant signs of cirrhosis on clinical examination and abdominal ultrasonograpy were enrolled in this study. Nine male and three female patients, with an average of 45 years were assigned to one of 3 groups according to their therapeutic preferences. Patients in group A received α interferon therapy, patients in group B received Chinese herbs therapy, patients in group C received combination therapy of α-interferon and Chinese herbs. All patients received treatment for 6 month. After treatment, there were two patients in group A with normalized ALT levels. One patient had a negative HCV RNA test result. Three patients had significant reductions in their HCV RNA titer. Patients in group B who received Chinese herbs, had no decrement in serum ALT or HCV RNA. Two patients in group C, who received combination therapy of α-interferon and Chinese herbs had normalized ALT levels and negative HCV RNA, while the adverse effects of the therapy were reduced compared to those patients who received α-interferon alone or Chinese herbs alone. The preliminary results of this study showed that the response rate of chronic hepatitis C to combination therapy of α-interferon and Chinese herbs was significantly higher than that of therapy with α-interferon alone or Chinese herbs alone, while the adverse effects were decreased. |
本系統中英文摘要資訊取自各篇刊載內容。