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題 名 | Potent Purine Nucleoside Phosphorylase Inhibitors:8-Aminoguanine Derivatives=嘌呤核苷磷解酶抑制劑: 8-胺基鳥糞素衍生物 |
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作 者 | 陳基旺; | 書刊名 | 醫學研究 |
卷 期 | 8:6 1988.05[民77.05] |
頁 次 | 頁357-365 |
分類號 | 418.4 |
關鍵詞 | 抑制劑; 衍生物; 胺基鳥糞素; 嘌呤核苷磷解酶; |
語 文 | 英文(English) |
中文摘要 | 近來發嘌呤核苷磷解酶(PNP)在T-淋巴細胞的活性比B-淋巴細胞高。因而引起普遍地重視成為一發展抑制劑的焦點,以期達到具有選擇性治療T-細胞血癌,對抗器官移植以後的組織排斥以及痛風。本文將介紹有關8-胺基鳥糞素發展成為PNP強抑制劑的方法。 |
英文摘要 | The recent finding that purine nucleoside phsophorylase (PNP) has high enzymatic activity in T-lymphocytes and low activity in a B-lymphocytes directs attention to PNP as a target for the design of inhibitors that could demonstrate specific action against T-cell leukemia, tissue rejection after organ transplantation and secondary gout. Our approaches towards the development of potent PNP inhibitors-8-aminoguanine derivaties are discussed. |
本系統中英文摘要資訊取自各篇刊載內容。