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| 題 名 | 抗癌藥物Doxorubicin產生之心臟毒性 |
|---|---|
| 作 者 | 黃偉修; 李偉政; 丁予安; | 書刊名 | 醫學研究 |
| 卷 期 | 8:4 1988.01[民77.01] |
| 頁 次 | 頁263-268 |
| 分類號 | 418.31 |
| 關鍵詞 | 心臟; 抗癌藥物; 毒性; |
| 語 文 | 中文(Chinese) |
| 中文摘要 | 四例癌症患者接受抗癌藥物Doxorubicin治療後,產生明顯的心臟功能不良。其中二例為乳癌患者,接受Doxorubicin治療累積劑量為525 mg/m²及400mg/m²,產生不可逆性之嚴重心臟衰竭。另一惡性淋巴瘤患者,接受Doxorubicin治療累積劑量高達785mg/m²,產生嚴重心臟功能不良。最後一例為小細胞肺癌患者,曾接受縱膈腔之放射線治療;再接受Doxorubicin雖劑量僅100mg/m²時,即產生心律不整之現象。藉此四例病患來報導Doxorubicin產生臨床心臟毒性副作用,並探討其可能相關因素,以祈減少產生心臟毒性之機會。 |
| 英文摘要 | Four patients in whom cardiac dysfunction developed after receiving doxorubicin were reported. Two patients with breast carcinoma after receiving 525 mg/m² and 400 mg/m² of doxorubicin suffered from irreversible congestive heart failure. One patient with Non-Hodgkin's lymphoma presented with cardiac dysfunction after receiving 785 mg/m² of doxorubicin. Another one patient with small cell carcinoma of lung who had radiotherapy to mediastinum previously, developed arrhythmia following by only (100 mg/m² doxorubicin treatment. Potential risk factor responsible for the development of doxorubicin-induced cardiotoxicity were reviewed. |
本系統中英文摘要資訊取自各篇刊載內容。