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| 題 名 | Lymphocyte Reactivity in Urologic Cancer Patients=泌尿道腫瘤病人淋巴球之刺激反應 |
|---|---|
| 作 者 | 于大雄; | 書刊名 | 醫學研究 |
| 卷 期 | 8:1 1987.07[民76.07] |
| 頁 次 | 頁9-16 |
| 分類號 | 415.1461 |
| 關鍵詞 | 反應; 刺激; 泌尿道; 病人; 淋巴球; 腫瘤; |
| 語 文 | 英文(English) |
| 中文摘要 | 我們在體外以植物性血球凝集素(PHA)刺激由22位正常人及50位泌尿道腫瘤之病人週邊血液所分離出來之淋巴球細胞。連續五天以臺盼蘭染料排除之方法計算淋巴球數目以決定每位病人淋巴球對PHA刺激後反應情形。非癌症病人淋巴球受PHA刺激後,一般都呈正相逐漸升高之趨勢。相反的,各種泌尿道腫瘤病人淋巴球接受到刺激後,大部份呈負相逐漸下降趨勢。於移行上皮細胞癌中可見到病人淋巴球反應度高低與癌症之臨床期別有密切關係,測定病灶有轉移之病人其反應度往往最低。我們追踪測定六位病人手術前及手術後淋巴球對PHA之反應度,發現無論病人最初病灶有無轉移,其淋巴球之刺激反應最少在4個月內不會有明顯差異產生。 |
| 英文摘要 | The in vitro reactivity of peripheral blood lymphocytes was determined in 22 controls and 50 patients with urologic cancers, including 33 urologic cancers, 8 renal cancers, 3 prostate cancers, and 6 other urologic cancers before operations. The proliferative response of lymphocytes to phytohemagglutinin (PHA-P) was measured by the trypan blue dye exclusion method. Non-cancer lymphocytes demonstrated a graded increasing trend during the 5-day stimulation course. By contrast, lymphocyte reactivity was significantly impaired in patients with urologic cancer by decreasing the trend during the stimulation course and did not correlate with the clinical behavior of the tumor. In most patients no rebound improvement of lymphocyte reactivity occurred following successful operations for the tumors. Correlations were presented for PHA responsiveness and tumor stage in urothelial cancer patients. |
本系統中英文摘要資訊取自各篇刊載內容。