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題名 | 小兒微小變化型腎病症候群之T淋巴球次群 |
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作者姓名(中文) | 陳志鑫; 謝貴雄; 李標柏; | 書刊名 | 中華民國小兒科醫學會雜誌 |
卷期 | 28:2 民76.03-04 |
頁次 | 頁105-107 |
分類號 | 417.574 |
關鍵詞 | 小兒微小變化型腎病症候群; T淋巴球次群; |
語文 | 中文(Chinese) |
中文摘要 | 淋巴球功能異常在腎病症候羣免疫病理作用機轉上佔一重要角色。本報告進一步研究淋巴球次羣在此病之變化。台北市立中興醫院小兒科於民國73年7月至74年12月,一年半中,區檢查10名急性微小變化型腎病症候羣病兒及17名恢複期病兒。利用間接免疫榮耀抗體法和T細胞單株抗體,計算總T淋巴球(OKT3),幫助性T淋巴球(OKT4),與壓制性T淋巴球(OKT8),並與25名年齡相鄰之正常兒童者做比較。結果小兒腎病症候羣於急性期之OKT3,OKT4,OKT8,與OKT4/OKT8比率分別爲73.38±10.65%,30.75±7.61%,39.75±8.48%與0.89%±0.30%,而於恢複期之OKT3,OKT4,OKT8與3OKT4/OKT8比率分別爲67.22±6.12%,38.12±8.36%,32.44±8.44%與1.24±0.32。即急性期,其壓制性T細胞有增加之現象(P<0.05),又恢複期病兒,其OKT8細胞仍然比正常兒童者高(P<0.05),而3OKT4/OKT8比率則仍然偏低(P<0.01)。 |
英文摘要 | Lymphocyte dysfunction has been postulated to play an important role in the pathogenesis of minimal change nephrotic syndrome (MCNS). In order to delineate more clearly the immunopathogenesis of MCNS, 10 children with acute MCNS, 17 children in remission stage and 25 age-matched normals were studied with respect to the distributions of T lymphocyte and its subsets defined by moneclonal antibodies. The diagnosis of MCNS was based on both clinical picture and renal biopsy. The results showed: 1) patients with acute MCNS had lower OKT4 helper T cells, higher OKT8 suppressor T cells and thus lower OKT4/OKT8 ratio than patients in remission had; and 2) even after remission, the OKT8 cell was still higher and OKT4/OKT8 ratio was still lower than those of normals. It is therefore concluded that increased suppressor T cell function may play a certain role in the immunopathogenesis of minimal change nephrotic syndrome. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。