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題 名 | 循環免疫複合物與B型肝炎之關係 |
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作 者 | 張木蘭; | 書刊名 | 醫學研究 |
卷 期 | 7:5 1987.03[民76.03] |
頁 次 | 頁263-269 |
分類號 | 415.5332 |
關鍵詞 | B型肝炎; 循環免疫複合物; |
語 文 | 中文(Chinese) |
中文摘要 | 本研究對37例急性B型肝炎,54例慢性B型肝炎住院患者,89例無症狀“健康”帶HBsAg者以及95名健康輸血員,使用改良之微版ELISA法進行血清中循環免疫複合物(Circulating immune complexes簡稱CICs)的測定。全部對象均測定SGPT和血清膽紅質。患者之血清均以放射免疫法測定HBsAg,anti-HBs,HBeAg,anti-HBe,anti-HBc,並對其中11例進行1至4個月的追踪隨訪觀察。結果發現CICs濃度(µg AHG eq-ml)在急性肝炎(45.45±18.8),慢性肝炎(35.5±18.16),無症狀帶HBsAg者(26.28±11.82)和正常人(13.07±5.95)呈依序遞減現象,各組間均有非常顯著之差異(p<0.02-0.001)。CICs與病理分型也有一定關係,慢性活動性肝炎(51.02±22.57)高於慢性小葉性肝炎(33.67±16.61)、慢性持續性肝炎(33.60±10.06)以及微小變化性肝炎(25.49±11.67),各組p值均小於0.02。追踪觀察的結果發現急性肝炎可分三型,其中B型和C型以及慢性活動性肝炎患者其CICs濃度下降之速度與肝功能恢復之情況均有密切的關係。此外我們發現慢性肝炎患者之CICs濃度在HBeAg陽性者高於在HBeAg陰性者,而在anti-HBe陰性者高於在anti-HBe陽性者。以上均說明CICs與B型肝炎之活動性以及預後有關。 |
英文摘要 | Circulating Immune Complexes (CICs) of 37 cases with acute hepatitis B, 54 cases with chronic hepatitis B, 89 cases of asymptomatic HBsAg carriers and 95 normal blood donors were measured by the modified micro-plate ELISA system. SGPT and serum bilirubin were measured for all of the above subjects; HBsAg, anti-HBs, HBeAg, anti-HBe, anti-HBc were measured by the radioimmunoassay among all of the patients. The concentration of CICs in patients with acute hepatitis (45.45±18.8), chronic hepatitis (35.50±18.16), asymptomatic HBsAg carriers (26.28±11.82) and normal subjects (13.07±5.95) formed a descend series. The differences between each group were statistically significant (p<0.02-0.001). The CICs concentration was also related to the pathological type of hepatitis: chronic active hepatitis (51.02±22.57) were significantly higher than chronic lobular hepatitis (33.67±16,61), chronic persistant hepatitis (33.60±10.06) and minimal change hepatitis (25.49±11.67). A longtitudinal study among 11 cases over a period of 1-4 months (average 2.5 months), showed that: 1. Three different types were distinguished among acute hepatitis B. 2. Two of the three acute type together with the chronic active hepatitis type showed the recovery of SGPT and serum bilirubin were closely related to the changes of CICs. In chronic hepatitis B the CICs concentration among patients with positive HBeAg was higher than that of patients with negative HBeAg. Contrarily, CICs concentration was higher in patients with negative anti-HBe than with positive anti-HBe, We concluded that CICs concentration is closely related to the activity and prognosis of hepatitis B. |
本系統中英文摘要資訊取自各篇刊載內容。