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題 名 | 椎管內注射Nalbuphine產生止痛作用在老鼠的研究 |
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作 者 | 蔡勝國; | 書刊名 | 中華民國外科醫學會雜誌 |
卷 期 | 18:4 1985.12[民74.12] |
頁 次 | 頁400-406 |
分類號 | 418.224 |
關鍵詞 | 椎管內注射Nalbuphine; 止痛; |
語 文 | 中文(Chinese) |
中文摘要 | Nalbuphine是一種兼具催動與拮抗雙重作用的新合成止痛劑。它能產生與嗎啡類似的止痛效果而無嗎啡會引起呼吸抑制的問題。本實驗是利用老鼠在顯微手術下直接從腰椎板植入椎管內導管,並注射10,20,30和40 μgkg-1等不同劑量的nalbuphine,以老鼠尾巴的閃尾反應時間測定注射前後產生止痛的變化。由實驗得知在老鼠椎管內注射40μgkg-1 nalbuphine可產生"完全有效止痛" (MPE100),與椎管內注射100 μgkg-1 morphine 所產生的"完全有效止痛"無明顯的差異,唯在維持"完全有效止痛"的時間nalbuphine為41分鐘,而morphine為44分鐘;從開始注射至產生"完全有效止痛"的時間,nalbuphine只需11分鐘,而morphine卻需16分鐘。同時由老鼠腹腔內注射1,5,10 mgkg-1的nalbuphine,發現在5 mgkg-1的劑量下才能開始產生"完全有效止痛",因此比較全身性與椎管注射產生完全有效止痛的劑量(ED 100)比率為125:1。實驗後老鼠的脊髓分別在椎管注射後24小時及2週,作成病理組織檢查皆無發現有任何急性或慢性的神經毒性反應的現象。 |
英文摘要 | Nalbuphine, a mixed agonist-antagonist narcotics, has been reported to possess a duration of action similar to morphine but less respiratory depression. This study was designed to evaluate the analgesic effect of nalbuphine, 10, 20, 30, 40 ug/kg, administered intrathecally in rats using the tail-flick test: Experiments were conducted in 30 wistar rats of male sex, weighing 200-250 gm. To facilitate the intrathecal administration of drugs into the spinal subarachnoid space of unrestrained rat, a 0.25 mm ID silicon catheter was inserted into the subarachnoid space of each rat under microscope, through a 1 mm hole drilled with a ball-shaped diamond drill in the mid-point of the lamina of 5th lumbar region. Only those rats which were undamaged neurologically in this preparational procedure were used in this study. Variable nalbuphine doses were delivered in a volume of 35 uL (including 5 uL air of dead space) with concentration of 10, 20, 30 and 40 ug/kg by a Hamilton gas-tight syringes. All tests for analgesia were carried out using the tail-flick test. For comparison, the TFL (Tail Flick Latency) measures were converted to maxirnum percentage effect (MPE), where MPE = (postinjection response latency-predrug response latency) / (cut-off-time-predrug respones latency) x 100%. The cut-off-time is 10 seconds in this study. The MPE changes after intrathecal administrations of nalbuphine 10, 20, 30 and 40 ug/kg were compared. Only 40 ug/kg nabuphine was seen to produce a significant analgesic effect (MPE 100) at 11 minutes after injection and lasted up to mean 41 minutes. Six rats received intrathecal injection of 100 ug/kg morphine, a significant effective analgesic effect (MPE 100) occurred at mean 16 minutes after injection and lasted up to mean 44 minutes. The amount of nalbuphine required to produce a sustained increase in nociceptive threshold is significantly greater when nalbuphine is given intraperitoneally as compared with intrathecally. The systemic-tointrathecal dose ratio was 125:1. All of the rats were sacrificed for histopathological examination of spinal cord and showed no changes attributed to injected nalbuphine or morphine. The results suggested that nalbuphine may have a direct analgesic effect on the spinal cords. The intrathecal administration of 40 ug/kg nalbuphine in rats produced an effective analgesic effect sirnilar to intrathecal 100 ug/kg morphine. The lack of adverse effects associated with intrathecal nalbuphine makes it an attractive alternative to intrathecal morphine for the relief of pain. |
本系統中英文摘要資訊取自各篇刊載內容。