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頁籤選單縮合
題名 | Oxidation of Glucose in Severely Septic Rats=大白鼠嚴重敗血症時對葡萄糖氧化能力之研究 |
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作者姓名(中文) | 陳維昭; | 書刊名 | 中華民國外科醫學會雜誌 |
卷期 | 18:1 1985.03[民74.03] |
頁次 | 頁1-7 |
分類號 | 415.136 |
關鍵詞 | 大白鼠; 敗血症; 葡萄糖氧化能力; |
語文 | 英文(English) |
中文摘要 | 外傷或敗血症時,常會出現一種"類糖尿病狀態",包括血糖升高及葡萄糖耐容能力之減低等。由於對能量之無法有效利用,加上蛋白破壞之增加,而使得這種病患易於發生各種合併症,並有很高的死亡率。如何有效地來支持這些病人的營養狀態,以改善其活命率,一直是臨床上一項重大的挑戰。在著者稍前的研究結果已經發現,在敗血症時大自鼠對外來脂肪之利用能力會受到抑制。但是即使在晚期敗血症時,對脂肪之利用能力也只減低約35%,顯示脂肪仍是可用的熱量源。但是脂肪和葡萄糖相比較,到底那一種較理想,則仍然不清楚,本研究卽在探討這種嚴重敗血症時,大白鼠對葡萄糖之利用情形到底如何? 先在大自鼠引發腹膜炎導致敗血症後,經由尾靜脈住入14C-glucose,然後比較研究敗血症組與對照組之間二氧化碳之產生以及血中各種營養基質濃度之異同。二氧化碳呼出之質驗結果顯示:二氧化碳呼出量之初期上升及隨後之下降敗血症組均要比對照組來得快,二氧化碳之頂點呼出量敗血症組此對照組高,達到頂點所需時間也比對照組短。在6小時的實驗期間對照組與敗血症組之累積二氧化碳呼出量分別為46.5±1.3%及52.5±0.8%。敗血症組顯著地高於對照組(P<0.005)。 測定血中各種營養基質濃度發現,敗血症組之血糖濃度反而比對照組低,血中三酸甘油脂之濃度則敗血症組比對照組高,胰島素及游離脂肪酸之濃度兩組之間並無顯著差異。 本研究結果顯示在這項實驗中之嚴重敗血症情形下,葡萄糖之產生能力已經減低,但葡萄糖被氧化之能力則不但沒有減低反而增加,此時對這些大白鼠供給葡萄糖,可以避免發生嚴重之低血糖,並可能提而減少死亡率。因此,在這種情況下葡萄糖是較理想的能量源。 |
英文摘要 | Effects of sepsis on the utilization of intravenously administered glucose was studied, using rats. Following the induction of abdominal sepsis in rats, 14 C-glucose was infused in a bolus and CO2 production was compared between control and septic rats. Results of the study revealed that septic rats demonstrated a greater rate of initial CO2 production, and subsequent decrease with a higher peak and shorter time to reach the peak, than the controls. Cumulative amounts of CO2 production in a six-hour period for control and septic rats were 46.5±l.3% and 52.5±0.8%, respectively. Septic rats produced CO2 more rapidly compared to the control rats (p<0.005). Measurement of concentrations of blood substrates at the end of the six-hour test showed lower glucose levels but higher triglyceride concentrations in the septic rats than the controls. Results of the study suggested that even in the relatively late stage of sepsis created in this study, glucose oxidation increased and glucose remains the energy substrate of choice. Provision of glucose to septic rats may prevent severe hypoglycemia with possible decrease in mortality. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。