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題名 | Hemolysis Due to Application of Silver Sulfadiazine in Burn Patients with G-6-PD Deficiency=使用Silver Sulfadiazine於灼傷病患帶G-6-PD缺乏症與溶血現象 |
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作者姓名(中文) | 陳宏基; 蔡裕銓; | 書刊名 | 中華民國外科醫學會雜誌 |
卷期 | 16:1 1983.03[民72.03] |
頁次 | 頁141-144 |
分類號 | 416.141 |
關鍵詞 | 灼傷病患帶; G-6-PD缺乏症; 溶血現象; |
語文 | 英文(English) |
中文摘要 | 在灼傷的治療中,Silver Sulfadiazine的使用越來越普遍,我們有必要對它做進一步的瞭解。一般認為它並沒有什麼副作用,其質不然。Silver Sulfadiazine塗在傷口上,銀離子極少被吸收,但是有一小部份的Sulfadiazine被吸收而進入體內,於是可能引起一些併發症。已有的報告是發熱反應及白血球降低,病人對細菌感染的抵抗力減少。在本文的病歷中,就G-6-PD缺乏症的患者加且分析,使用Silver Sulfadiazine的結果的確可以引起溶血現象,我們曾加以注意而停止用藥。 結論是:雖然目前在治療燙傷時G-6-PD並非例行檢查的項目之一,但是如果在使用Silver Sulfadiazine當中病人一直有溶血現象,或是燙傷急性期已過而病人仍有無法解釋的貧血,則應作G-6-PD的檢查。 |
英文摘要 | Silver Sulfadiazine, one of the topical agents used in the treatment of burn wounds for controlling pseudomonas aeruginosa, has been proven very effective and is used popularly. Yet the side effects from Silver Sulfadiazine have not been emphasized. Silver ions delivered on the wound surface are rarely absorbed, but Sulfadiazine absorbed from the wound may cause complications such as increased body ternperature, leucopenia and decreased host resistance to bacteria. Patients sustained from bum injury with G-6-PD deficiency were analysed. Silver Sulfadiazine caused hemolysis in cases with, G-6-PD deficiency and the drug should be discontinued. Determination of G-6-PD is not a routine procedure in treating bum patients, but in cases with persistent hemolysis or unexplainable anemia after recovery from acute phase, G-6-PD should be checked. |
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