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| 題 名 | 中醫治療成人T細胞淋巴瘤皮膚表現病例報告=Traditional Chinese Medicine in the Treatment of Adult T-cell Lymphoma with Skin Manifestations: A Case Report |
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| 作 者 | 張众珩; 陳冠文; 黃琬云; 張正杰; | 書刊名 | 中醫藥雜誌 |
| 卷 期 | 36:2 2025.12[民114.12] |
| 頁 次 | 頁73-95 |
| 分類號 | 413.26 |
| 關鍵詞 | 成人T細胞白血病-淋巴瘤; 皮膚表徵; 中醫藥; 大青葉; Adult T-cell leukemia/lymphoma; Cutaneous manifestations; Traditional Chinese medicine; Isatis indigotica; |
| 語 文 | 中文(Chinese) |
| DOI | 10.6940/JCM.202512_36(2).05 |
| 中文摘要 | 此案例報告為一名62歲女性確診成人T細胞白血病-淋巴瘤合併皮膚斑塊結節,病灶表現出紅色斑塊結節伴隨搔癢疼痛,因類固醇及照光治療效果不明顯故尋求中醫治療,持續服用中藥後,皮膚紅色斑塊病灶改善許多,可見中醫治療效果顯著。淋巴瘤在中醫觀點上認為和痰凝、血瘀及毒熱有關。患者根據辨證論治為熱毒內蘊、血熱風燥,因此使用清熱解毒、涼血祛風治法,方藥選擇上主要使用大青葉、金銀花、蒲公英、黃連解毒湯等解毒瀉火的中藥,再加上白鮮皮、水牛角等祛風涼血的藥物,經過半年的治療,取得明顯的成效。成人T細胞白血病-淋巴瘤(Adult T-cell leukemia/lymphoma)簡稱為ATLL,依據疾病不同時期而有不同的臨床症狀及臟器侵犯,除了淋巴結腫大、肝脾腫大及肺部侵犯,患者若併發皮膚病灶常需使用類固醇或照光治療。目前文獻較缺乏針對成人T細胞白血病-淋巴瘤的中醫治療探討,本案例報告亦整理大青葉的抗腫瘤活性機轉及臨床應用。 |
| 英文摘要 | This case report describes a 62-year-old woman diagnosed with adult T-cell leukemia/lymphoma (ATLL) suffered from cutaneous plaques and nodules for several years. The lesions presented as red papule, plaques and nodules accompanied by itching and pain. Due to limited improvement after steroid and phototherapy, the patient sought traditional Chinese medicine (TCM) for alternative management. After continuous use of Chinese herbal medicine, the skin lesions showed significant improvement, indicating the effectiveness of TCM treatment. From the perspective of TCM, lymphoma is believed to be associated with phlegm accumulation, blood stasis, and toxic heat. According to syndrome differentiation, the patient was diagnosed with internal accumulation of toxic heat, blood heat, and wind-dryness. Therefore, the treatment focused on clearing heat and detoxifying, cooling the blood, and dispelling wind. The selected formula included Da Qing Ye (Isatis leaf), Huang Lian Jie Du Tang (Coptis Detoxification Decoction), Jin Yin Hua (honeysuckle), and Pu Gong Ying (dandelion) for detoxifying and reducing internal heat, combined with Bai Xian Pi (Dictamnus bark) and Shui Niu Jiao (water buffalo horn) to dispel wind and cool the blood. After six months of treatment, the patient achieved significant improvement. Adult T-cell leukemia/lymphoma (ATLL) presents with various clinical symptoms and organ involvement depending on the stage of the disease. In addition to lymphadenopathy, hepatosplenomegaly, and pulmonary infiltration, patients with cutaneous lesions are often treated with steroids or phototherapy. Currently, there is limited literature discussing the application of TCM in the treatment of ATLL. This case report also summarizes the antitumor mechanisms and clinical applications of Da Qing Ye. |
本系統中英文摘要資訊取自各篇刊載內容。