頁籤選單縮合
| 題 名 | To Integrate Point-of-Care and Laboratory Automation System of BNP Testing=BNP檢測在POCT和自動化軌道系統間之整合 |
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| 作 者 | 楊美娥; 張心馨; 林靜宜; 陳冀寬; | 書刊名 | Journal of Biomedical & Laboratory Sciences |
| 卷 期 | 29:3 2017.10[民106.10] |
| 頁 次 | 頁99-103 |
| 分類號 | 415.12 |
| 關鍵詞 | B型排鈉利尿胜肽; 氨基未端B型排鈉利尿胜肽錢體; 重點床邊照護; BNP; NT-ProBNP; POCT; |
| 語 文 | 英文(English) |
| 中文摘要 | 美國心臟醫學會建議可以使用利鈉胜肽(Natriuretic peptide)因子的檢測幫助心衰竭診斷,如: BNP 和NT-proBNP。目前市面上有許多BNP和NT-proBNP的商品化檢測試劑,包含了床邊檢測系統 (Point-of-Care testing, POCT)和自動化實驗室系統。兩種系統各有其獨特的優點,例如: POC系統 具有很短的報告時效(turnaround time, TAT);自動化系統則有高運載量和高效能的特性。根據本 研究結果,Triage® BNP在Triage® MeterPro (POCT) 和Beckman® DxI600 (自動化系統)間具有良 好的相關性(Beckman BNP = 1.095 xTriage BNP- 20.85, R=09938)。因此,我們可以利用其不同的 系統特性,先使用Triage® BNP進行快速診斷(TAT=24.7分鐘,較自動化系統TAT=38.3分鐘快速); 對於確診為心衰竭而入院的病人,再利用自動化系統進行追蹤檢測。此外,由於Triage®系統也能 執行NT-proBNP的檢測,在本實驗中也進行了BNP和NT-proBNP的臨床效能比較。結果顯示,BNP 和NT-proBNP的一致性為86.8%(陽性一致性為100%,陰性一致性為79.5%)。值得注意的是,有部 分非心衰竭的病人出現NT-proBNP數值升高的情況,暗示著可能有某些因子會造成NT-proBNP偽 陽性,值得我們未來進一步探討。 |
| 英文摘要 | This study compares the BNP correlation between point-of-care (POC) system and the automated laboratory system. Each system owns their unique characteristics. POC system is a global trend aiming to obtain patient data in short turnaround time (TAT), but automated system has high throughput and high quality performance. According to the results, Triage® BNP performs good correlation between Triage® MeterPro (POC system) and Beckman® DxI600 (Beckman BNP = 1.095 xTriage BNP- 20.85, R=09938). This means that we can diagnose emergency patients by in a short TAT, then monitoring the heart failure inpatients by Beckman system (true TAT: 24.7 mins vs. 38.3 mins). In addition, we also investigate the clinical performance of BNP and NT-proBNP on Triage® system. The total agreement between BNP and NT-proBNP was 86.8% (positive agreement is 100%, negative agreement is 79.5%). It should be note that some non-HF patients show elevated NT-proBNP results. It demonstrates that there might be some factors cause the false positive and worth to do the further investigation. |
本系統中英文摘要資訊取自各篇刊載內容。