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頁籤選單縮合
| 題 名 | Establishment of Reference Intervals for the Coagulation Molecules in a Taiwanese Population=建立臺灣區域人口血液凝固分子生物參考區間 |
|---|---|
| 作 者 | 鄭進裕; 張碧珠; 張志新; 林賓賓; 許呈安; | 書刊名 | Journal of Biomedical & Laboratory Sciences |
| 卷 期 | 30:2 2018.06[民107.06] |
| 頁 次 | 頁57-63 |
| 分類號 | 415.124 |
| 關鍵詞 | 生物參考區間; 血液凝固; 第八凝固因子; Reference intervals; Coagulation; VWF:Ag; VWF:RCo; Factor VIII; |
| 語 文 | 英文(English) |
| 中文摘要 | 背景:建立在地區域人種之每項凝血因子的參考區間是非常重要。緣起是一般製造商所提供的生物參考區間主要來自西方人群或參考文獻資料,並非屬於在地性區域人種的生物參考區間。在凝血分子檢查數值,是很容易受不同儀器產牌和試劑而有所影響。在本次研究中,我們採用來自西門子的試劑分別用於Sysmex CA1500和(Behring Coagulation Timer, BCT)儀器上進行分析。根據臨床實驗室標準作業指引手冊(Clinical and Laboratory Standard Institute, CLSI),我們選定分析台灣人口族群,來進行本次評估對象,並排除有出血史、血栓性疾病史、慢性肝臟疾病史及可能影響凝血因子之對象。我們一共建立出凝血酶原時間、活化部分凝血質時間、凝血酶原時間、纖維蛋白原分解產物和D-二聚體、凝血因子、S蛋白功能、C蛋白功能、抗凝血酶III、α_(2-)抗纖溶酶功能纖溶酶原、纖溶酶原激活物抑制物-1、VWF抗原,VWF:RCo、LA1和LA2,並更進一步建立 第八凝固因子與VWF:Ag和VWF:RCo中O型和非O型血型的生物參考區間,可提供給在地區域各家醫院作為血液凝固檢查生物參考值依據。 |
| 英文摘要 | Background: Establishment of reference intervals of each coagulation factor for a population is very important. The reference intervals provided by manufacturers were mostly obtained from Western populations or literatures. Particularly, the values of coagulation molecules are significantly affected by different instruments and reagents. Methods: In this study, reagents from Siemens were used on the Sysmex CA1500 and Behring Coagulation Timer (BCT) instruments. We performed the coagulation tests in a Taiwanese population according to the Clinical and Laboratory Standard Institute (CLSI) guidelines. Clinical exclusion criteria were history of bleeding or thrombotic diseases, chronic liver disorders, and those could affect levels of coagulation factors. Results: The new reference intervals for the PT, aPTT, TT, fibrinogen, FDP, and D-Dimer, coagulation factors, protein S, protein C, antithrombin III, α2-antiplasmin, plasminogen, plasminogen activator inhibitor-I, VWF:Ag, VWF:RCo, LA1 and LA2, were well determined. The reference intervals for type O and type non-O blood groups in FVIII, VWF:Ag and VWF:RCo were further established. Conclusion: The reference intervals established in this study could be used as fundamental data for clinical use and adopted in other clinical laboratories after further verification. |
本系統中英文摘要資訊取自各篇刊載內容。