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| 題 名 | 人類乳突病毒檢測在子宮頸癌篩檢中的初步成果:探索性研究=Preliminary Outcomes of Human Papillomavirus DNA Testing in Cervical Cancer Screening: A Pilot Study |
|---|---|
| 作 者 | 潘俞樺; 鄭嘉薇; 洪珮容; 蕭可妤; 陳正杰; | 書刊名 | Journal of Biomedical & Laboratory Sciences |
| 卷 期 | 37:3 2025.09[民114.09] |
| 頁 次 | 頁149-162 |
| 分類號 | 417.2832 |
| 關鍵詞 | 子宮頸癌篩檢; 人類乳突病毒; 敏感度; Cervical cancer screening; Human papillomavirus; Diagnostic sensitivity; |
| 語 文 | 中文(Chinese) |
| 中文摘要 | 高風險人類乳突病毒 (HR-HPV)是子宮頸癌的致病因子。HR-HPV testing 為世界衛生組織建議的第一線 篩檢工具之一。國內現今缺乏 HR-HPV testing 篩檢的結果,本研究目的為評估 primary HPV DNA testing 與 co-testing 的篩檢效能。由實驗室資訊系統中,納入接受子宮頸癌篩檢病人,收集 HR-HPV testing、Pap test 與組織切片診斷結果,以組織切片診斷為參考標準,計算 HR-HPV testing 與 co-testing 的診斷效能。HR-HPV testing 偵測出高惡性度鱗狀細胞上皮內病變(含)以上敏感度為 96.3%,co-testing 敏感度為 91.8%。根據研究結果,HR-HPV testing 與 co-testing 推測為敏感的篩檢工具。 |
| 英文摘要 | High risk human papillomavirus (HR-HPV) is the causative agent of cervical cancer. HR-HPV testing is currently one of the first-line screening tools recommended by the World Health Organization. There is a paucity of data regarding HR-HPV screening outcomes in Taiwan. The purpose of this study was to evaluate the efficacy of primary HPV DNA testing and co-testing. Patients screened for cervical cancer were enrolled from the laboratory information system, and the diagnostic results of HR-HPV testing, Pap test, and histopathology were collected. In this study, we employed histopathology as the reference standard. The sensitivity of HR-HPV testing for detecting high-grade squamous intraepithelial lesion (or worse) was 96.3%, and the sensitivity of co-testing was 91.8%. According to the outcomes of our study, HR-HPV testing and co-testing are presumed to be sensitive screening tools. |
本系統中英文摘要資訊取自各篇刊載內容。