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| 題 名 | 從B-CLL轉變為T-PLL的罕見案例:流式細胞儀檢驗在臨床上的應用=A Rare Case of Transformation from B-CLL to T-PLL: Clinical Application of Flow Cytometry |
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| 作 者 | 劉又榕; 許呈安; 施佩君; | 書刊名 | Journal of Biomedical & Laboratory Sciences |
| 卷 期 | 37:1 2025.03[民114.03] |
| 頁 次 | 頁11-18 |
| 分類號 | 415.12 |
| 關鍵詞 | 流式細胞儀; 淋巴瘤篩檢管; T細胞淋巴瘤螢光抗體套組; T細胞前淋巴球性白血病; B細胞淋巴球性白血病; Flow cytometry; LST; T-CLPD; T-PLL; B-CLL; |
| 語 文 | 中文(Chinese) |
| 中文摘要 | 此案病人原先在他院被診斷為 B 細胞淋巴球性白血病(B-cell chronic lymphocytic leukemia,B-CLL), 治療兩年後病人的白血球總數仍居高不下,經病理檢查顯示無原先的 B 細胞惡性腫瘤, 然而卻觀察到 疑似異常 T 細胞的表現。 因此,本實驗室先以淋巴瘤篩檢管 (Lymphoid Screening Tube,LST ) 執行 流式細胞儀分析,發現 T 細胞表面標記表現異常,因此加做更完整的(T-cell chronic lymphoproliferative disorder, T-CLPD ) T 細胞淋巴瘤螢光抗體套組,結果顯示已變為 T 細胞前淋巴球性白血病(T-PLL), 此篇文章將介紹本實驗室如何運用流式細胞儀檢驗,以協助醫師診斷。 |
| 英文摘要 | The patient was originally diagnosed with B-cell chronic lymphocytic leukemia (B-CLL) at a different healthcare facility and underwent a pathological re-evaluation due to persistent leukocytosis despite two years of treatment. The report showed the absence of the original malignant cells, but indicated a suspicion of an abnormal cluster of T cells. Our laboratory conducted a flow cytometric analysis by using lymphoid screening tubes (LST) for flow cytometry analysis, we confirmed the abnormal T-cell population. This prompted us to perform a comprehensive T-cell chronic lymphoproliferative disorder (T-CLPD) panel. The results suggested a transformation into T-cell prolymphocytic leukemia (T-PLL). The aim of this article is to describe the use of flow cytometry analysis in our laboratory for the rapid diagnosis of such cases. |
本系統中英文摘要資訊取自各篇刊載內容。