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| 題 名 | 評估年齡、BMI、BPH與TBS對骨密度及骨折風險在骨質疏鬆前期病人的影響:回溯性研究=Evaluated of the Effects of Age, BMI, BPH, and TBS on Bone Mineral Density and Fracture Risk in Patients with Pre-osteoporosis: A Retrospective Study |
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| 作 者 | 陳保良; 王昱豐; 廖建國; 莊紫翎; | 書刊名 | Annals of Nuclear Medicine and Molecular Imaging |
| 卷 期 | 38:3 2025.09[民114.09] |
| 頁 次 | 頁77-93 |
| 分類號 | 416.67 |
| 關鍵詞 | 骨質密度; 良性前列腺肥大; 骨折風險評估工具; 骨小樑指數; Benign prostatic hyperplasia; BPH; Bone mineral density; BMD; Fracture risk assessment tool; FRAX®; TBS FRAX® trabecular bone score; TBS FRAX® TBS; |
| 語 文 | 中文(Chinese) |
| DOI | 10.6332/ANMMI.202509_38(3).0001 |
| 中文摘要 | 背景:本研究探討腰椎骨質密度 (bone mineral density, BMD) 增加在正常前 列腺 (normal prostate, NP) 與良性前列腺肥大 (benign prostatic hyperplasia, BPH) 中的影響,並在不同 BMD 狀態下(正常 [normal]、低骨質密度 [low bone density, LBD]、骨質疏鬆 [osteoporosis, OP]),利用骨小樑指數 (trabecular bone score, TBS),骨折風險評估工具 (fracture risk assessment tool, FRAX® ) 及骨小樑指數骨折風險評估工具 (trabecular bone score fracture risk assessment tool, TBS FRAX® ) 分析其對兩組間增加骨折率的影響關係。 方法:本研究是一篇回溯性研究,於臺灣南部某區域教學醫院預防醫學中心 健檢資料進行分析,收集了 2014 年 6 月至 2021 年 4 月間,受檢者年齡介於 50 歲以上至 98 歲的健檢男性,共計 2,768 名。執行 BMD 與超音波檢查是 否有 BPH,經轉換分析後得到 TBS 數值,以 FRAX® 與 TBS FRAX® 進一步 計算十年骨折率。 結果:本篇研究發現,在 BPH 與 NP 相比,BPH 組腰椎 BMD 都增加,特 別是在 BMD 分級中正常 (p = 0.034) 與 LBD (p < 0.001) 階段,而 TBS 只 有在 OP (p = 0.026) 組有顯著差異,FRAX® 與 TBS FRAX® 是在正常 (p < 0.001) 與 LBD (p < 0.001) 階段就有顯著的差異。 結論:本研究顯示,BPH 造成腰椎 BMD 增加,經調整 BMI 和年齡後消失, 因此;BPH 與腰椎 BMD 間應無因果關係,雖然,相較於 NP 組,BPH 組 的腰椎 BMD 更高,特別是在 LBD 發生之前。研究也確定了年齡、BMI、 BPH 與 BMD 及 TBS 之間的相關性。根據這些發現,本研究強烈建議,對 於患有 BPH 的個體,應同時進行 BMD 檢測,並結合 TBS、FRAX® 和 TBS 調整後的 FRAX® 進行全面的骨骼評估,以評估骨骼狀況及骨折風險,後續 其相關性與機轉但仍須進一步探討。 |
| 英文摘要 | Background: This study investigated the impact of increased lumbar spine bone mineral density (BMD) on normal prostate (NP) and benign prostatic hyperplasia (BPH). It further analyzed the effects of different BMD states (normal, low bone density [LBD], and osteoporosis [OP]) on fracture risk between the two groups. The analysis utilized trabecular bone score (TBS), the fracture risk assessment tool (FRAX®), and the trabecular bone score fracture risk assessment tool (TBS FRAX®) to evaluated the differences in fracture rate increases. Methods: This study is a retrospective analysis conducted using health examination data from the preventive medicine center of a regional teaching hospital in southern Taiwan. A total of 2,768 male participants aged between 50 and 98 years were included, with data collected from June 2014 to April 2021. BMD measurements and ultrasound examinations were performed to determine the presence of BPH. The TBS values were obtained through conversion analysis, and the 10-year fracture risk was subsequently calculated using FRAX® and TBS FRAX® . Results: This study found that lumbar spine BMD was higher in the BPH group compared to the NP group, particularly in the normal (p = 0.034) and LBD (p < 0.001) stages of BMD classification. However, TBS showed a significant difference only in the OP group (p = 0.026). In contrast, FRAX® and TBS FRAX® demonstrated significant differences as early as the normal (p < 0.001) and LBD (p < 0.001) stages. Conclusion: This study revealed showed that BPH caused an increase in lumbar spine BMD, which disappeared after adjustment for BMI and age; therefore, there should be no causal relationship between BPH and lumbar spine BMD, although the lumbar spine BMD was higher in the BPH group compared with the NP group, especially before the onset of LBD. The study also identified correlations between age, BMI, BPH, BMD, and TBS. Based on these findings, this study strongly recommends that individuals with BPH should undergo a comprehensive skeletal assessment in combination with BMD testing, TBS, FRAX®, and TBS-adjusted FRAX® to assess bone status and fracture risk, although their associations and mechanisms need to be further explored. |
本系統中英文摘要資訊取自各篇刊載內容。