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| 題 名 | 香蕉皮萃取物對紫外光誘發皮膚損傷的保護效果及免疫調節功能=Protective Effects of Banana Peel Extract on UV-Induced Skin Damage and Its Immune Modulation Function |
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| 作 者 | 陳駿威; 張富貴; 張基昌; 洪哲穎; 洪永瀚; | 書刊名 | 臺灣營養學會雜誌 |
| 卷 期 | 48:3 2024.09[民113.09] |
| 頁 次 | 頁85-96 |
| 分類號 | 425.3 |
| 關鍵詞 | 紫外光B; 皮膚損傷; 香蕉皮萃取物; 免疫調節; Ultraviolet B; Skin damage; Banana peel extract; Immune regulation; |
| 語 文 | 中文(Chinese) |
| DOI | 10.6691/NSJ.202403_48(3).0002 |
| 中文摘要 | 紫外線 B(UVB)是導致皮膚損傷及光老化的主要因素之一。本研究旨在探討香蕉皮萃取 物對 UVB 誘發皮膚光損傷的保護作用,並評估其對免疫反應及維生素 D 代謝的影響。首先,我們 利用細胞培養實驗分析不同分層的香蕉皮萃取物的抗光損傷效果。結果顯示,水層區分物(wW) 在 200 g/mL 濃度下顯著提高 UVB 照射後角質細胞的存活率,並降低 IL-6 及活性氧物質(ROS) 的產生。在後續動物實驗中將該水層區分物以BPE簡稱。在動物實驗中,對照組小鼠在UVB照射 後皮膚厚度顯著增加,而塗抹BPE(10.6 mg/mouse)的組別則顯示皮膚厚度有明顯減少。此外, 先行管餵補充BPE(80 mg/kgBW)有效降低UVB引起的表皮厚度增加,並改善膠原蛋白的損失。 另外,UVB 照射導致小鼠脾臟中 IFN- 生成量顯著降低,而 IL-6 生成量則增加。值得注意的是, BPE 的補充能提高 IFN- 的生成,並降低 IL-6 的生成,顯示出調節 Th1/Th2 比例的潛力。綜上所 述,本研究證實BPE在抗UVB光損傷及調節免疫反應的潛力,可為皮膚保護素材的應用提供重要 參考。 |
| 英文摘要 | Ultraviolet B (UVB) is one of the major factors leading to skin damage and photoaging. This study aims to investigate the protective effects of banana peel extract on UVB-induced skin damage and to evaluate its impact on immune response and vitamin D metabolism. Firstly, we conducted cell culture experiments to analyze the photoprotective effects of different fractions of banana peel extract. The results showed that the water fraction (wW) at a concentration of 200 g/mL significantly increased the survival rate of keratinocytes after UVB exposure and reduced the production of IL-6 and reactive oxygen species (ROS). This water fraction was subsequently referred to as banana peel extract (BPE) in following experiments. In the animal studies, the control group of mice exhibited a significant increase in skin thickness after UVB exposure, while the group treated with BPE (10.6 mg/mouse, skin application) showed a trend to decrease skin thickness. Additionally, supplementation of BPE (80 mg/kg BW, oral tube-feeding) effectively reduced the increase in epidermal thickness induced by UVB and improved collagen loss. Moreover, UVB exposure caused a significant decrease in the production of IFN- in the spleens of mice, while the production of IL-6 increased. Notably, BPE supplementation was able to elevate IFN- levels and reduce IL-6 levels, indicating its potential to regulate the Th1/Th2 ratio. In conclusion, this study confirms the potential of BPE in protecting against UVB-induced skin damage and modulating immune responses, providing important references for the use of skin protection materials. |
本系統中英文摘要資訊取自各篇刊載內容。