查詢結果分析
來源資料
頁籤選單縮合
| 題 名 | 探討益生質在慢性腎臟病中的潛力:現有證據與未來方向=Exploring the Potential of Synbiotics in Chronic Kidney Disease: Current Evidence and Future Directions |
|---|---|
| 作 者 | 劉文治; 方德昭; | 書刊名 | 內科學誌 |
| 卷 期 | 36:2 2025.04[民114.04] |
| 頁 次 | 頁99-114 |
| 分類號 | 415.81 |
| 關鍵詞 | 慢性腎臟病; 腸道微菌叢失調; 腸腎軸; 益生質; 益生菌; 益生元; Chronic kidney disease; CKD; Gut microbiota dysbiosis; Gut-kidney axis; Synbiotics; Probiotics; Prebiotics; |
| 語 文 | 中文(Chinese) |
| DOI | 10.6314/JIMT.202504_36(2).02 |
| 中文摘要 | 慢性腎臟病(Chronic Kidney Disease, CKD)是高併發症發生率及死亡率的進行性疾病,心 血管疾病(Cardiovascular disease, CVD)是CKD的主要致病和致死原因之一。CKD破壞腸道微 菌叢,導致腸道微菌叢組成和數量的失衡,改變腸道的代謝功能:過多的腸源性尿毒素破壞 腸道壁的緊密連接(tight junction),誘發全身性發炎反應,導致CVD;另一方面,異常的腸道 微菌叢藉由增加的氧化壓力及發炎反應,再次惡化腎功能,形成腸-腎軸的惡性循環。因此供 給適當的益生質(益生菌及益生元),能增進腸道微菌叢的健康而提升對腎臟的保護力,防 止CKD的惡化。本篇綜論擬討論腸道微菌叢失調與CKD間如何相互影響及益生質在減緩腎 臟惡化所扮演的角色,作為CKD新的輔助治療策略。 |
| 英文摘要 | Chronic Kidney Disease (CKD) is a progressive disease with a high incidence of complications and mortality. Cardiovascular disease (CVD) is one of the primary causes of morbidity and mortality in CKD patients. CKD disrupts the gut microbiota, leading to imbalances in its composition and quantity, and altering intestinal metabolic functions. Excessive gut-derived uremic toxins damage the intestinal tight junctions, triggering systemic inflammatory responses that contribute to CVD. Conversely, abnormal gut microbiota, through increased oxidative stress and inflammation, further impairs kidney function, creating a vicious cycle in the gut-kidney axis. Therefore, providing appropriate probiotics and prebiotics can improve gut microbiota health, enhancing kidney protection and preventing CKD progression. This review aims to explore the interplay between gut microbiota dysbiosis and CKD, and the role of probiotics and prebiotics in slowing kidney deterioration, offering a new adjunctive therapeutic strategy for CKD. |
本系統中英文摘要資訊取自各篇刊載內容。