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相關文獻
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頁籤選單縮合
| 題 名 | Small Cell Neuroendocrine Carcinoma of the Renal Pelvis--A Case Report and Literature Review=腎盂小細胞神經內分泌癌:一病例報告及論文回顧 |
|---|---|
| 作 者 | 陳奕先; 翁啟倫; 周詠欽; | 書刊名 | 輔仁醫學期刊 |
| 卷 期 | 22:4 2024.12[民113.12] |
| 頁 次 | 頁33-39 |
| 分類號 | 415.8072 |
| 關鍵詞 | 血尿; 神經內分泌; 腎盂; 小細胞癌; Hematuria; Neuroendocrine; Renal pelvis; Small cell carcinoma; |
| 語 文 | 英文(English) |
| DOI | 10.53106/181020932024122204004 |
| 中文摘要 | 目的:報告一例罕見的腎盂小細胞神經內分泌癌。病例報告:一名 58 歲女性因 持續兩週的無痛性肉眼血尿就診。診間腎臟超音波檢查顯示右側腎積水伴隨有腎 盂部的腫塊。電腦斷層掃描顯示右側腎盂有一 3 厘米局限性腫塊,導致右側腎積 水。病患接受了右側腎盂尿管切除術並膀胱袖口切除。在顯微鏡下觀察,腫瘤細 胞顯示出小細胞神經內分泌癌的典型特徵,例如相對較小的細胞、高的核質比、 不明顯的細胞邊緣和稀少的細胞質。腫瘤細胞的免疫組織化學研究顯示,細胞角 蛋白和 GATA-3 染色呈陽性。神經內分泌鑑別顯示出突觸素、嗜鉻蛋白 A 和 CD56 染色呈陽性。她被轉介到我們的醫學腫瘤科進行輔助化療。手術後九個月的影像 檢查未發現局部復發或遠處轉移的跡象。結論和重要性:由於案例報告有限,在 手術前沒有明確的影像學徵象可以與其他腎腫瘤加以區分。一旦確診,由於其強 侵襲性的生長模式,術後輔助治療是必要的。 |
| 英文摘要 | Purpose: To present a rare clinical presentation of renal pelvis small cell neuroendocrine carcinoma. Case report: A 58-year-old female visited our urology department due to painless gross hematuria for two weeks. A renal ultrasound revealed right-side hydronephrosis with a mass lesion on the renal pelvis. Enhanced computerized tomography demonstrated a 3 cm localized enhanced mass on the right renal pelvis causing right hydronephrosis. A right nephroureterectomy with bladder cuff resection was performed. Microscopically, the tumor cells showed typical features of small cell neuroendocrine carcinomas, such as relatively small cells, a high N:C ratio, poorly defined cell borders, and scant cytoplasm. Immunohistochemical studies revealed that the tumor cells were positive for cytokeratin and GATA-3. Neuroendocrine differentiation demonstrated positive staining for synaptophysin, chromogranin A, and CD56. The patient was referred to the medical oncology department for adjuvant chemotherapy. Follow-up imaging at 9 months showed no signs of local recurrence or distant metastasis. Conclusion and Importance: There is no definite radiologic sign to differentiate renal pelvis small cell neuroendocrine carcinoma from other kidney tumors preoperatively at present due to limited case reports. Once diagnosed, postoperative adjuvant therapy is mandatory due to its vigorous growth pattern. |
本系統中英文摘要資訊取自各篇刊載內容。