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頁籤選單縮合
| 題 名 | 治療骨髓纖維化藥物之JAK抑制劑新進展=Advances of JAK Inhibitors in the Treatment of Patients with Myelofibrosis |
|---|---|
| 作 者 | 高育青; | 書刊名 | 內科學誌 |
| 卷 期 | 36:1 2025.02[民114.02] |
| 頁 次 | 頁33-43 |
| 分類號 | 415.6 |
| 關鍵詞 | 骨髓纖維化; JAK抑制劑; 骨髓增生性疾病; Myelofibrosis; JAK inhibitor; Myeloproliferative neoplasms; |
| 語 文 | 中文(Chinese) |
| DOI | 10.6314/JIMT.202502_36(1).05 |
| 中文摘要 | 骨髓纖維化(Myelofibrosis, MF)是骨髓增生性疾病之一,分為原發性(Primary myelofibrosis, PMF)和次發性骨髓纖維化(Secondary myelofibrosis, SMF)包含真性紅血球增生症後的骨髓纖維化(Post-polycythemia vera, PPV-MF)和原發性血小板增多症後的骨髓纖維化(Post essential thrombocyhemia, PET-MF)。臨床表現除了血球異常之外,也包含脾臟腫大及全身性症狀:疲勞、發燒、盜汗、體重減輕等。而異常的JAK/STAT訊號傳遞路徑是造成骨髓纖維化重要的致病原因,因此JAK抑制劑的使用可改善PMF和SMF造成的相關症狀。近幾年有越來越多的JAK抑制劑上市且被核准於此適應症,本文回顧了JAK抑制劑治療骨髓纖維化的最新進展。 |
| 英文摘要 | Myelofibrosis (MF) is a myeloproliferative neoplasm, and composed of primary MF and secondary myelofibrosis, including post-polycythemia vera MF and post essential thrombocyhemia MF. Patients with MF may presented with splenomegaly, and have constitutional symptoms, such as fatigue, night sweats, fever, weight loss. The pathogenesis of MF is associated with activation of the JAK/STAT pathway, resulting in clonal hematopoiesis, fibrotic replacement of the bone marrow, extramedullary hematopoiesis, splenomegaly, and debilitating constitutional symptoms. Therefore, JAK inhibitors play important role in the treatment of MF. Recently, more and more studies regarding of different JAK inhibitors were reported and approved by US FDA in clinical practice. Here, we review the JAK inhibitors in the treatment of MF. |
本系統中英文摘要資訊取自各篇刊載內容。