頁籤選單縮合
| 題 名 | 流感大流行疫苗之儲備初探=Overview of the Pandemic Influenza Vaccine Stockpiling Strategies |
|---|---|
| 作 者 | 施雲瑞; 王任鑫; 池宜倩; 周淑玫; 陳昶勳; | 書刊名 | 疫情報導 |
| 卷 期 | 35:18 2019.09.24[民108.09.24] |
| 頁 次 | 頁252-261 |
| 分類號 | 412.42 |
| 關鍵詞 | 流感大流行; 大流行前疫苗; 大流行疫苗; 預購協議; Pandemic influenza; H5N1; Pre-pandemic vaccine; Pandemic vaccine; Advanced Purchase Agreement; APA; |
| 語 文 | 中文(Chinese) |
| 中文摘要 | 依世界衛生組織統計,自2003年起,全球陸續發生人類H5N1流感疫情。為因應流感大流行之風險,我國於2006年起進行大流行前疫苗(pre-pandemic vaccines)儲備。國際間儲備策略包括儲備實體疫苗、抗原原液、佐劑及簽訂疫苗預購協議(advanced purchase agreement, APA)等。近年國際間儲備策略趨勢漸以簽訂APA為主,致國外廠產製實體大流行前疫苗量減少。本文重新檢視我國儲備策略,探討實體儲備及預購協議之優缺點,並蒐集國際間多元儲備模式進行比較。 經比較各項疫苗儲備策略,簽訂APA為大流行疫苗儲備中較為妥適之策略,可確保我國於大流行發生時有優先取得吻合流行病毒株之疫苗的權利。此外,因造成流感大流行之病毒型別不確定性高,簽訂APA可降低每年儲備單一病毒株型別大流行前疫苗耗費之經費,並避免儲備實體大流行前疫苗產品所可能遭遇大流行病毒株變異之風險。 |
| 英文摘要 | According to the World Health Organization, more and more confirmed human cases of H5N1 infections have been reported all over the world since 2003. Facing pandemic influenza threats, Taiwan has been stockpiling pre-pandemic influenza vaccines since 2006. International stockpile strategies for pandemic influenza vaccine include storage of pre-pandemic influenza vaccines, bulk vaccine antigen, adjuvants and the signing advanced purchase agreements (APA) with manufacturers. Because APA leads to a reduction in the manufacturing of pre-pandemic influenza vaccines, it became a trend worldwide in recent years. We re-examined and evaluated our national strategy for stockpile of vaccines, antigens, adjuvants and APA. In comparison with the present various stocking strategies, APA is a more appropriate strategy that ensures that the health authority has the priority to obtain vaccines matching the virus strains in circulation of a pandemic. In addition, since the virus strain causing the next influenza pandemic is highly uncertain, APA saves annual cost of pre-pandemic vaccine procurement and avoid the risk of stockpiling a pre-pandemic influenza vaccine with unmatched pandemic virus strains. |
本系統中英文摘要資訊取自各篇刊載內容。