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頁籤選單縮合
題名 | Omalizumab在氣喘治療的簡介=Introduction of Omalizumab in Asthma Treatment |
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作者 | 陳雅娟; 蕭惠娟; 王程遠; | 書刊名 | 藥學雜誌 |
卷期 | 33:2=131 2017.06[民106.06] |
頁次 | 頁41-45 |
分類號 | 415.425 |
關鍵詞 | 氣喘; 單株抗體; Omalizumab; Anti-IgE monoclonal antibody; |
語文 | 中文(Chinese) |
中文摘要 | IgE 在造成氣喘的機轉中佔有重要的中介角色,會結合位於肥大細胞 (mast cell)、 嗜鹼性白血球 (basophil) 細胞,嗜伊紅性白血球 (eosinophil) 及樹突細胞 (dendritic cell) 表面的高親和力 IgE 接受體 (FcεRI),進而造成一連串化學物質的分泌,最終造成氣 喘的相關症狀。Omalizumab 是唯一上市的 anti-IgE 單株抗體,在 IgE 引發下游反應前 先將 IgE 結合掉,用於治療對傳統吸入型氣管擴張劑及吸入型類固醇效果不佳的氣喘 患者,可以減少急性發作、下降住院機會及增進生活品質的效果。Omalizumab 大致 上是耐受性良好且安全的藥物,副作用多以局部皮膚反應為主,但在寄生蟲感染高危 群者,以及有血管炎的患者,仍要小心使用。其長期的效果仍需追蹤期更長的研究來 加以釐清。 |
英文摘要 | Immunoglobulin E (IgE) plays an important mediating role for mechanism of asthma by binding to the high-affinity IgE receptor (FcεRI) which found on the surface of mast cell, basophil, eosinophil and dendritic cell. Further, it will also come to a series of chemical secretion and cause related asthma symptoms finally. Only omalizumab is approved antilgE monoclonal antibody in the market and it can bind IgE before IgE induced down-stream response. Also, for asthma treatment of the traditional inhaled bronchodilators and steroids poor control patient, it can reduce exacerbation acutely, hospitalization and make life quality better. Omalizumab has been shown well-tolerated and safety drug. Most side effects are partial skin reactions, however, the high-risk parasitic infections and vasculitis should take care for taking medicine. As for the long-term effect, it will still take some time to follow up and study for further clarification. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。