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來源資料
頁籤選單縮合
題名 | 「菌醫生多功能潔淨液」為具有高效殺菌力之消毒劑="Dr. Germ, a Multi-function Cleaner with Moisturizer" Is a Highly Effective Disinfectant |
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作者姓名(中文) | 蔡文城; 宋采純; | 書刊名 | 檢驗及品保雜誌 |
卷期 | 9:2 2020[民109] |
頁次 | 頁55-65 |
分類號 | 461.6 |
關鍵詞 | 菌醫生多功能潔淨液; 實驗室殺菌能力; 口服急毒性試驗; 高效殺菌; Dr. Germ; A multi-function cleaner with moisturizer; Acute oral toxicity; High-level disinfectant; |
語文 | 中文(Chinese) |
中文摘要 | 本試驗係根據DGHM(German Society for Hygiene and Microbiology)的定量懸浮液試驗(A quantitative suspension test: the in vitro test)評估啟新生物科技有限公司所提供之試驗物質「菌醫生多功能潔淨液」(以下稱為試驗物質)對臨床常見的(i)抗藥性菌株包括甲氧西林(methicillin)抗性金黃色葡萄球菌(methicillin-resistant Staphylococcus aureus, MRSA)、萬古黴素抗性腸球菌(vancomycin-resistant Enterococcus, VRE)、多重抗藥性不動桿菌(pandrug-resistant Acinetobacter baumannii, PDR-AB)、大腸桿菌ESBLs株(Escherichia coli ESBLs strains)與多重抗藥性綠膿桿菌(multidrug-resistant Pseudomonas aeruginosa, MDR-PA);(ii)真正病原菌包括鼠傷寒沙門氏菌(Salmonella typhimurium)、淋病奈瑟氏菌(Neisseria gonorrhoeae)與結核分枝桿菌(Mycobacterium tuberculosis);(iii)真菌包括白色念珠菌(Candida albicans)與巴西麴菌(Aspergillus brasiliensis,又稱黑黴菌)以及(iv)產芽胞細菌包括枯草芽胞桿菌(Bacillus subtilis)與產氣莢膜梭菌(Clostridium perfringens)之實驗室(in vitro)殺菌能力。測試時,以1 mL(約10^5 CFU/mL)的不同菌種/株濃度分別與9 mL試驗物質作用1分鐘後,再評估其實驗室殺菌能力。結果顯示試驗物質與MRSA、VRE、PDR-AB、大腸桿菌ESBLs株、MDR-PA、鼠傷寒沙門氏菌、淋病奈瑟氏菌、結核分枝桿菌及白色念珠菌作用後皆具有100%之殺菌率,而與枯草芽胞桿菌及產氣莢膜梭菌作用後亦達到99%以上之殺菌率,另外,與巴西黴菌作用亦顯示高消毒力。因此,根據Spaulding的分類,試驗物質屬於高效殺菌力的消毒劑。本研究亦進行試驗物質之大鼠口服急毒性試驗,測試時,以口服方式依5 mL/kg體重之劑量將試驗物質管餵予各試驗大鼠(Sprague-Dawley)後連續觀察14天,觀察試驗大鼠是否發生死亡或出現任何異常臨床症狀測試結果發現各試驗大鼠均存活,且未出現任何異常之臨床症狀及體重正常。總之,「菌醫生多功能潔淨液」於本試驗設計條件下具有高效(high-level)殺菌能力,且對大鼠不具有口服急毒性。 |
英文摘要 | The antimicrobial activity of "Dr. Germ, a multi-function cleaner with moisturizer" provided by the Creative LifeScience Co. (hereafter referred to as the test substance) was evaluated. The test was performed according to the guidelines of DGHM (German Society for Hygiene and Microbiology) on the following categories of microorganisms: (i) drug resistant species/strains, including methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE), pandrug-resistant Acinetobacter baumannii (PDR-AB), Escherichia coli ESBLs strains, and multidrug-resistant Pseudomonas aeruginosa (MDR-PA); (ii) frank pathogens, including Salmonella typhimurium, Neisseria gonorrhoeae, and Mycobacterium tuberculosis; (iii) fungi, including Candida albicans and Aspergillus brasiliensis; and (iv) spore-forming bacteria, including Bacillus subtilis and Clostridium perfringens. During the test, 1 mL suspension (10^5 CFUs /mL) of each microorganism was mixed with 9 mL of the test substance and incubated for 1 minute, followed by culture. The results showed that the test substance had 100% antimicrobial activity against MRSA, VRE, PDRAB, Escherichia coli ESBLs strains, MDR-PA, Salmonella typhimurium, Neisseria gonorrhoeae, Mycobacterium tuberculosis, and Candida albicans. It also had a bactericidal rate of more than 99% on spore-forming bacteria, Bacillus subtilis and Clostridium perfringens and an excellent disinfection effect on Aspergillus brasiliensis. Based on the Spaulding classification for device disinfection, the test substance was classified as a high-level disinfectant. The acute oral toxicity of the test substance was assessed by tube feeding each test rat (Sprague Dawley) with 5 mL/kg body weight of the test substance and then observing for 14 days. Results showed that all test rats survived without any abnormal clinical symptoms and loss of body weight. Taken together, we conclude that "Dr. Germ, a multi-function cleaner with moisturizer" is a highly effective disinfectant with no acute oral toxicity. |
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