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| 題 名 | 金菩薩引起下肢水腫--案例與討論=Olanzapine Induce Petal Edema: A Case Report and Discussion |
|---|---|
| 作 者 | 陳彥宏; 陳正宗; | 書刊名 | 藥學雜誌 |
| 卷 期 | 35:4=141 2019.12[民108.12] |
| 頁 次 | 頁90-94 |
| 分類號 | 418.21 |
| 關鍵詞 | 第二代抗精神病劑; 下肢水腫; Olanzapine; |
| 語 文 | 中文(Chinese) |
| 中文摘要 | 第二代抗精神病劑 (second generation antipsychotics),比起第一代抗精神病劑,大 幅地減少了錐體外徑 (extrapyramidal symptoms) 方面的副作用,且具有更多治療上的 優點。Olanzapine 屬於第二代抗精神病劑,用在治療精神相關疾患,不過發生體重增 加副作用的機率也比較高。 藥物引起之水腫常發生於鈣離子阻斷劑、非類固醇抗發炎藥類 NSAIDs、其他血 管擴張劑、乙型阻斷劑等。隨著使用普及,第二代抗精神病劑引起之不良反應案例陸 續被報導,單一由金菩薩藥物 (olanzapine) 引起下肢水腫之案例極少見,國內未有此 報導。我們報導一件因服用 olanzapine 引起下肢水腫之案例並於停藥後症狀自發性消 失,試著排除干擾因素及評估因果關係,並以文獻回顧探討抗精神病劑造成水腫可能 之因素,提供國內精神醫療照護人員參考。 |
| 英文摘要 | Second generation antipsychotics (SGA) have been reported to reduce the adverse effects of extrapyramidal symptoms (EPS) considerably as compared to first generation antipsychotics (FGA). Olanzapine is a SGA used to treat mentally related disorders. The efficacy of olanzapine is considered superior to FGA, but the adverse effect of weight gain was reported more frequent than other atypical agents. Although olanzapine is widely used, some adverse effects have been reported. The incidence of the adverse effects such as olanzapine induce petal edema is rare. There was no such reports in Taiwan. Edema can be observed as side-effect of many medications, such as calcium channel blockers, nonsteroidal anti-inflammatory drugs, vasodilators and beta blockers. We presented here the case of olanzapine-induced petal edema which relieved spontaneously after stopping the drug. We have ruled out the other reasons to induce edema and assessed the causality between causing edema and using olanzapine base on literature reviews. |
本系統中英文摘要資訊取自各篇刊載內容。