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題 名 | 秋水仙素引起透析病人肌病變探討=Colchicine-induced Myopathy: A Case Report |
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作 者 | 顏寧瑤; 鄭雅芳; 蔡慈貞; | 書刊名 | 藥學雜誌 |
卷 期 | 35:3=140 2019.09[民108.09] |
頁 次 | 頁117-123 |
分類號 | 418.2133 |
關鍵詞 | 秋水仙素; 肌病變; 腹膜透析; Colchicine; Myopathy; Dialysis; ADR; |
語 文 | 中文(Chinese) |
中文摘要 | Colchicine 在臨床上用於痛風的治療已多年,常見的副作用以腸胃道不適為主, 而慢性腎衰竭的病人則有較高的風險出現神經肌肉方面的病變。本案例為一名54歲男 性,患有末期腎臟病接受腹膜透析治療,急性痛風發作使用 colchicine 0.5 mg QD 治療 一個月後,出現肌肉無力伴隨 creatine kinase 值升高 (1460 U/L)、肌電圖及體感覺誘發 電位檢查結果異常之現象,入院經檢查及評估,排除可能原因後,懷疑為 colchicine 導致神經肌肉病變之不良反應,而症狀在停藥後逐漸改善。藉由此案例的分享,提醒 醫療人員,透析病人使用 colchicine,建議調降劑量為0.3 mg BIW,並留意可能發生的 不常見但嚴重之併發症。 |
英文摘要 | Colchicine has been used for the treatment of gout for centuries. The main side effect is gastrointestinal intolerance. The patients with chronic renal failure have higher risk of developing neuromyopathy. This case is a 54-year-old male with end-stage renal disease under peritoneal dialysis. Muscle weakness developed after acute gout therapy with colchicine 0.5 mg QD for 1 month. Laboratory studies showed elevated creatine kinase level (1460 U/L). Electromyography and nerve conduction velocity test results were abnormal. A series of examinations were done to rule out possible causes and discontinue colchicine due to suspicion of drug-induced myopathy. The muscle weakness gradually improved and CK level normalized after withdrawal of colchicine. We report this case is to remind the medical staff about the importance of colchicine dose adjustment, which was suggested 0.3 mg BIW in the dialysis population. Also, be aware of the uncommon but serious complications. |
本系統中英文摘要資訊取自各篇刊載內容。