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題名 | 淺談人類生長激素缺乏症及治療概述=Discussion on Human Growth Hormone Deficiency and Treatment Overview |
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作者 | 魏振峰; 湯松陵; 黃志偉; 李宜勳; | 書刊名 | 藥學雜誌 |
卷期 | 35:3=140 2019.09[民108.09] |
頁次 | 頁26-31 |
分類號 | 415.663 |
關鍵詞 | 生長激素缺乏症; 下視丘; 腦下垂體腫瘤; 身材矮小疾病; |
語文 | 中文(Chinese) |
中文摘要 | 生長激素缺乏症 (growth hormone deficiency,GHD) 是一種罕見疾病,最常造成 的原因是下視丘或腦下垂體腫瘤,其特徵在於身體組成、碳水化合物、脂質代謝、骨 密度及心血管風險的改變。近三十年來,長期觀察性研究、臨床試驗和統合分析等文 獻,提供了生長激素替代療法在生長激素缺乏症患者中的療效和安全性之相關訊息。 本文回顧的目的是提高我們對 GHD 診斷和治療的認識,並概述 FDA 批准可用於兒 童和成人患者之適應症,將有助於患有生長障礙或身材矮小疾病的患者接受必要的治 療,以增加線性生長並改善生活品質。 |
英文摘要 | Growth hormone (GH) deficiency is a rare disorder, which most commonly results from a hypothalamic or pituitary tumors, and is characterized by alterations in body composition, carbohydrate, lipid metabolism, bone mineral density and cardiovascular risk profile. Over the last three decades, short- and long-term observational studies, clinical trials and metaanalyses have provided relevant information on the efficacy and safety of growth hormone replacement therapy in persons with GH deficiency (GHD). The aims of this review are to advance our understanding on the diagnosis and treatment of GHD and to summarize the guidelines that are available for all FDA-approved indications among children and adults. Adherence to these guidelines will help to ensure that patients with disorders of growth failure or short stature receive the necessary therapy to increase linear growth and improve quality of life. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。