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題名 | 骨質疏鬆症老年患者雙磷酸鹽治療後發生雙側非典型股骨骨折--個案報告=Osteoporosis in the Elderly Patient with Bilateral Atypical Femoral Fracture after Bisphosphonate Treatment |
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作者姓名(中文) | 楊皓宇; 梁志光; 陳弘哲; 周明岳; 林育德; 姚智國; 陳如意; | 書刊名 | 臺灣老年醫學暨老年學雜誌 |
卷期 | 14:2 2019.05[民108.05] |
頁次 | 頁105-114 |
分類號 | 415.596 |
關鍵詞 | 骨質疏鬆症; 老年人; 雙磷酸鹽類; 非典型股骨骨折; Osteoporosis; Atypical femoral fracture; Bisphosphonates; Elderly; |
語文 | 中文(Chinese) |
中文摘要 | 隨著人類壽命的延長,骨質疏鬆症已是全球第二大的重要流行病,僅次於心血管疾病。因此預防和治療骨質疏鬆症是處於人口老化快速的台灣所要面對的重要課題。骨質疏鬆症是一種因全身性低骨量及骨頭微小結構破壞,導致骨折風險增加的疾病。雙磷酸鹽類是全世界用於治療骨質疏鬆症的最常用的藥物之一,但越來越多的證據顯示,長期使用雙磷酸鹽會增加非典型骨折的風險。本文報告一位患有全身性紅斑狼瘡長期服用類固醇,同時因骨質疏鬆症服用雙磷酸鹽類約十年的老年病人,發生雙側非典型股骨骨折的案例。我們將對此病人的危險因子、藥物使用、後續治療及追蹤等做進一步的討論。 |
英文摘要 | With the extension of human life span, osteoporosis is the second common epidemic disease in the world, second to cardiovascular disease. Therefore, the prevention and treatment of osteoporosis is an important issue in Taiwan because of its rapidly aging population. Osteoporosis is a disease that results in increased risk of fracture due to systemic low bone mass and the destruction of bone microarchitecture. Most menopausal women are caused by aging and lack of estrogen to enhance bone resorption, in addition to consider whether there are secondary causes such as steroid use. The clinical diagnosis of osteoporosis can be either fragility fractures or bone mineral density (BMD) measured by a dual energy X-ray absorptiometry (DXA). Treatment of osteoporosis involves proper lifestyle and medication. Bisphosphonates are one of the most commonly used drugs in the world for the treatment of osteoporosis, but more and more evidence shows that long-term use of bisphosphonates increases the risk of atypical fractures. This article reports a case of bilateral atypical femoral fractures in an elderly patient with systemic lupus erythematosus who took steroid control for a long time and bisphosphonates due to osteoporosis for about ten years. We will discuss the risk factors, drug use, further treatment, and follow-up. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。