頁籤選單縮合
題名 | 外敷Phenytoin治療壓瘡之探討=Topical Phenytoin for Treating Pressure Ulcers |
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作者姓名(中文) | 林怡儂; 陳佳玲; 楊玉琳; | 書刊名 | 藥學雜誌 |
卷期 | 35:1=138 2019.03[民108.03] |
頁次 | 頁59-64 |
分類號 | 418.21 |
關鍵詞 | 壓瘡; 褥瘡; Pressure ulcer; Bedsore; Decubitus ulcer; Wound healing; Phenytoin; |
語文 | 中文(Chinese) |
中文摘要 | 壓瘡是組織受到無法緩解的壓迫發生損傷所造成的病變。除了讓病人受苦外,壓 瘡也會延長住院天數與增加照護費用。目前對於第一期與第二期壓瘡使用親水性膠體 敷料即有效。 Phenytoin 是一個抗癲癇藥物,其齒齦增生的副作用被認為是癒合傷口的一個契 機。Phenytoin 涉及多個癒合過程,譬如增加膠原與其他結締組織、降低細菌污染與滲 出液的量。外敷 phenytoin 在第三期與第四期壓瘡會較有治療角色存在。因為全身吸收 性小,使用外敷 phenytoin 時未見一般口服 phenytoin 的副作用。因為溶解度低與 PH 值高,使用 phenytoin 的錠劑、膠囊及注射劑型於外敷可能會造成刺痛與灼熱感,然而 病人可能因為痛覺受器已受損所以不覺那麼疼痛。對於適當的外敷劑量與研發劑型仍 需要進一步的臨床研究做確認。 |
英文摘要 | Pressure ulcers (PUs) are lesions caused by unrelieved pressure that results in damage to the underlying tissue. Apart from causing suffering to patients, PUs also result in increased length of hospital stay and cost of health care. Modern available dressings such as hydrocolloids work well in Stage I and II PUs. Phenytoin is an anticonvulsant drug and gingival hyperplasia is recognized as its adverse effect, which suggested possible use as a healing agent in wounds. Phenytoin may be involved in several healing process such as promoting deposition of collagen and other connective tissue, decreasing bacterial contamination and reducing wound exudate production. Topical phenytoin play a significant role in Stage III and IV PUs. The side effects of oral phenytoin have not been reported in the topical phenytoin for wound healing because of the minimal systemic absorption. The formulation of phenytoin solution from pills, capsules or intravenous use is inconvenient for topical use because of low solubility and high pH, which may have stinging and burning sensations. In PU the pain is absent or reduced due to destruction of sensory receptors. Further clinical trials are recommended to evaluate the optimal topical dose and the use of a delivery vehicle. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。