頁籤選單縮合
題名 | 淺談全身性肥大細胞增生症=The Treatment of Systemic Mastcytosis |
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作者 | 童玟津; 郭正睿; 簡素玉; | 書刊名 | 藥學雜誌 |
卷期 | 35:1=138 2019.03[民108.03] |
頁次 | 頁54-58 |
分類號 | 415.6 |
關鍵詞 | 全身性肥大細胞增生症; 皮膚肥大細胞增生症; KIT突變; Systemic mastosis; Cutaneous mastocytosis; Mast/stem cell growth factor receptor; KIT mutations; |
語文 | 中文(Chinese) |
中文摘要 | 肥大細胞增生症,為身體的肥大細胞病態性的累積在組織中,又分為全身性與皮 膚性。全身性肥大細胞增生症 (systemic mastosis, 簡稱 SM) 屬於罕見疾病,較常發生 於成人時期,為過多的肥大細胞浸潤且侵犯一種或多重器官為特色的疾病。只侷限於 皮膚的肥大細胞增生症稱為皮膚肥大細胞增生症 (cutaneous mastocytosis, 簡稱 CM), 通常較常出現於兒童,大部分屬良性自癒。 全身性肥大細胞增生症,於臨床上依據病程被分為四種亞型,依據骨髓檢查和臨 床症狀,與予正確的亞型診斷,進而給予適當的治療,才能獲得較佳的預後。目前認 為此疾病與 KIT (mast/stem cell growth factor receptor, 肥大或幹細胞生長因子受體) 突變 有關,針對晚期全身性肥大細胞增生症,尚無有效明確的治療方法。 |
英文摘要 | Mastocytosis describes a group of disorders in which there is pathologic accumulation of mast cells in tissues. These diseases can be limited to the skin (cutaneous mastocytosis ,CM) or involve extracutaneous tissues (systemic mastocytosis, SM). SM is a rare disease that occurs more frequently in adulthood and is characterized by excessive mast cell accumulation and infiltration of one or more organs. CM is usually found more often in children and mostly spontaneously regresses. SM is divided into four subtypes, based on bone marrow examination and clinical symptoms, and to the correct diagnosis of subtypes, and then give appropriate treatment in order to obtain a better prognosis. Now, the disease is thought to be associated with KIT mutations. There is no effective and definite treatment for advanced systemic mastocytosis. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。