頁籤選單縮合
題名 | 持續性及頑固性打嗝的治療=Treatment for Persistent Hiccups and Intractable Hiccups |
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作者姓名(中文) | 楊璦瑜; 蔡憶萱; 劉錦鳳; 郭震羣; | 書刊名 | 藥學雜誌 |
卷期 | 35:1=138 2019.03[民108.03] |
頁次 | 頁14-19 |
分類號 | 415.9 |
關鍵詞 | 持續性打嗝; 頑固性打嗝; Persistent hiccups; Intractable hiccups; Chlorpromazine; |
語文 | 中文(Chinese) |
中文摘要 | 一次打嗝發作 (a hiccup bout) 是常見且通常是短暫的症狀,但“持續性打 嗝” (persistent hiccups) 是持續時間超過48小時,不超過一個月。“頑固性打嗝” (intractable hiccups) 是持續時間超過一個月的打嗝。通常打嗝不需要進行醫學評估, 但持續性或頑固性打嗝需要徹底評估以確定潛在的病因。在藥物治療之前,先排除 潛在的病因,例如停用可能引起打嗝的藥物,使用氫離子幫浦阻斷劑 (proton pump inhibitor;PPI) 或 H2受體拮抗劑 (H2 blockers) 治療胃食道逆流。 持續性或頑固性打嗝是一種相對罕見的症狀,因而描述藥物治療的研究證據有 限,大多數的研究多為非對照性回顧或前瞻性病例觀察。Chlorpromazine 是唯一經美 國食品衛生管理局核准用於打嗝的藥物。Baclofen、gabapentin 及 metoclopramide 在 前瞻性的研究顯現療效,建議作為持續性或頑固性打嗝的選擇。希望藉由治療改善病 人的症狀、提升生活品質。 |
英文摘要 | Hiccups are a common and usually transient condition, however "persistent hiccups" are hiccups that continue longer than 48 hours and no longer than one month, "intractable hiccups" are hiccups that continue longer than one month. Bouts of hiccups are usually do not require medical evaluation, however persistent and intractable hiccups may necessitate a thorough medical evaluation. Before drug treatment, the management of hiccups should be directed at the underlying cause as much as possible (eg, stopping a potentially offending medication; using a proton pump inhibitor to treat gastroesophageal reflux disease). Persistent and intractable hiccups is a relatively rare phenomenon, and there is limited evidence describing the efficacy of pharmacotherapy to treat the condition, the major patients described were in noncontrolled retrospective or prospective case series. Chlorpromazine is the only drug approved by the US Food and Drug Administration for the treatment of hiccups. Baclofen, gabapentin, and metoclopramide were the drugs found positive results in prospective studies and are good options to use when treating persistent and intractable hiccups. We hope the treatment can improve the symptoms of hiccups and improve quality of patients’ life. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。